A Randomized, Controlled Double Blind Acute Study: Effects of Protein Blends on Muscle Protein Synthesis and Breakdown
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Muscle Protein Synthesis or Fractional synthesis rate (FSR)
研究概览
简要总结
Soy protein is a high quality, plant-based protein that is comparable to milk, meat and eggs. Soy protein has a digestion rate (intermediate) compared to whey (fast) and casein (slow). This intermediate rate may allow soy protein to have an extended window of muscle protein synthesis that has not been monitored in previous studies. While most of the sports nutrition "recovery" products are dairy-based protein blends (high in branched-chain amino acids), soy protein offers additional benefits that can make an important contribution to these types of sports nutrition products. Soy protein contains approximately 300% more arginine and 30% more glutamine compared to whey protein and these two amino acids may bring additional benefits (immunity and hydration, respectively) to athletes. A "blend" of high-quality proteins (soy and dairy) may be the optimal sports nutrition product for athletes to consume following training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-35 yrs
- •Stable body weight for at least 1 year
排除标准
- •Exercise training (>2 weekly sessions of moderate to high intensity aerobic or resistance exercise)
- •Significant heart, liver, kidney, blood, or respiratory disease
- •Peripheral vascular disease
- •Diabetes mellitus or other untreated endocrine disease
- •Active cancer (all groups) and history of cancer (groups potentially randomizable to rapamycin)
- •Acute infectious disease or history of chronic infections (e.g. TB, hepatitis, HIV, herpes)
- •Recent (within 6 months) treatment with anabolic steroids, or corticosteroids.
- •Alcohol or drug abuse
- •Tobacco use (smoking or chewing)
- •Malnutrition (BMI < 20 kg/m2, hypoalbuminemia, and/or hypotransferrinemia)
- •Obesity (BMI > 30 kg/m2)
- •Low hemoglobin levels (below normal values)
- •Food allergies
- •Taking dietary supplements such as green tea, etc.
- •Currently on a high-soy diet (consuming >2 servings of soy per day)
研究组 & 干预措施
Protein Blend (soy, whey and casein)
干预措施: Protein Blend (Other)
Whey Protein Isolate
干预措施: Protein Blend (Other)
结局指标
主要结局
Muscle Protein Synthesis or Fractional synthesis rate (FSR)
时间窗: baseline, 3 hours, 5 hours
The fractional synthesis rate (FSR) of mixed muscle proteins will be calculated from the incorporation rate of L-\[ring-13C6\]Phenylalanine into the mixed muscle proteins, and the free-tissue phenylalanine enrichment.
次要结局
- oxidative and inflammatory markers(baseline, 3 hours, 5 hours)
- Phosphorylation of protein in muscle protein signaling pathways(baseline, 3 hours, 5 hours)