Effect of Metabolic Dysfunction in Branched-chain Amino Acids on Cardiac Function in Patients With Sepsis: an Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 主要终点
- The incidence of Sepsis induced cardiomyopathy
研究概览
简要总结
The current project was designed to examine the effects of BCAA metabolic dysfunction on cardiac function in septic patients.
详细描述
Patients with sepsis and with/without type 2 diabetes will be included. Patients prospectively collected the following indicators in the intensive care unit: 1. myocardial injury-related biomarkers: troponin T and B natriuretic peptide levels; 2. cardiac structure-related indicators: the size of the left and right ventricle, left ventricular ejection fraction, etc.3. septic cardiomyopathy incidence: Troponin T>0.01ng/ml is the standard for the diagnosis of septic cardiomyopathy. Additionally, the investigators will collect the peripheral blood at preoperative, day 1, day 3, and day 5 after surgery. Peripheral blood plasma and PBMCs were separated by differential centrifugation: the concentration of BCAAs in serum and PBMCs; the expression of PBMCs BCAAs metabolic enzymes BCAT 1, BCKDH, and PP 2 Cm by WB; and the levels of AST, ALT, LDH, CK, and CK-MB
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients diagnosed with sepsis with or without type 2 diabetes
排除标准
- •patients with immunodeficient diseases patients who accept glucocorticoid or immunosuppressant patients with an age younger than 18 years patients who cannot provide informed consent
结局指标
主要结局
The incidence of Sepsis induced cardiomyopathy
时间窗: up to 7 days post-ICU admission, or at hospital discharge, whichever comes first
Diagnostic criteria for Sepsis induced cardiomyopathy, TroponinT \> 0.01 ng/ml
次要结局
- Plasma levels of type B natriuretic peptide(up to 7 days post-ICU admission, or at hospital discharge, whichever comes first)
- Plasma levels of TroponinT(up to 7 days post-ICU admission, or at hospital discharge, whichever comes first)
- Left ventricular and right ventricular size(up to 7 days post-ICU admission, or at hospital discharge, whichever comes first)
- ejection fraction(up to 7 days post-ICU admission, or at hospital discharge, whichever comes first)
研究者
Chunling Jiang
Professor
West China Hospital