Role of ET-1, Physical Activity, and Sedentary Behavior in Microvascular Dysfunction Following GDM
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- amount of microvascular insulin-mediated dilation
研究概览
简要总结
Women with a history of gestational diabetes mellitus (GDM) are at a 2-fold greater risk for the development of overt cardiovascular disease (CVD) following the effected pregnancy. While subsequent development of type II diabetes elevates this risk, prior GDM is an independent risk factor for CVD morbidity, particularly, within the first decade postpartum. GDM is associated with impaired endothelial function during pregnancy and decrements in macro- and microvascular function persist postpartum, despite the remission of insulin resistance following delivery. Collectively, while the association between GDM and elevated lifetime CVD risk is clear, and available evidence demonstrates a link between GDM and vascular dysfunction in the decade following pregnancy, the mechanisms mediating this persistent dysfunction remain unexamined.
The purpose of this investigation is to examine the role of endothelin-1, a potent vasoconstrictor, in aberrant microvascular function in otherwise healthy women with a history of GDM and to identify whether this mechanism is influenced by physical activity and sedentary behavior.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •history of pregnancy within 5 years of the study visit
- •had healthy pregnancy OR had gestational diabetes diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes.
排除标准
- •skin diseases,
- •current tobacco or electronic cigarette/vape pen use,
- •diagnosed or suspected hepatic or metabolic disease including diabetes,
- •statin or other cholesterol-lowering medication,
- •current antihypertensive medication,
- •history of preeclampsia or gestational hypertension
- •current hypertension,
- •current pregnancy,
- •body mass index <18.5 kg/m2,
- •allergy to materials used during the experiment.(e.g. latex), known allergies to study drugs.
研究组 & 干预措施
local lactated Ringer's perfusion
lactated Ringer's is perfused through the microdialysis fiber to serve as the vehicle control
干预措施: Insulin aspart (Drug)
local L-NAME perfusion
local L-NAME is perfused through the microdialysis fiber to inhibit nitric oxide synthase
干预措施: Insulin aspart (Drug)
local BQ-788 and BQ-123 perfusion
local ET-1 inhibitors perfused through the microdialysis fiber to serve as the experimental treatment
干预措施: Insulin aspart (Drug)
local BQ-788 + BQ-123 + L-NAME perfusion
local ET-1 inhibitors and L-NAME are perfused through the microdialysis fiber to inhibit nitric oxide synthase during the experimental treatment
干预措施: Insulin aspart (Drug)
结局指标
主要结局
amount of microvascular insulin-mediated dilation
时间窗: at the study visit, an average of 4 hours
cutaneous vascular vasodilator responses to insulin perfusion in lactated Ringer's, BQ 788 and BQ-123, and L-NAME treated microdialysis sites
次要结局
未报告次要终点
研究者
Anna Stanhewicz, PhD
Assistant Professor
University of Iowa