Does Remote Ischemic Preconditioning Reduce the Incidence of Postoperative Atrial Fibrillation in Patient Undergoing Coronary Artery Bypass Graft Surgery?
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Heart Diseases
- Sponsor
- Norwegian University of Science and Technology
- Enrollment
- 92
- Locations
- 1
- Primary Endpoint
- Postoperative atrial fibrillation
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Objectives: Despite utilization of available means for cardioprotection during cardiac surgery, myocardial injury still occurs. Further improvement of cardioprotection is therefore necessary. Remote ischemic preconditioning (RIPC) is an easy and non-invasive method. Laboratory research has shown promising results regarding myocardial survival during open heart surgery, but the clinical value of RIPC is still largely unknown. The investigators hypothesize that RIPC before coronary artery bypass grafting (CABG) reduces the incidence of postoperative atrial fibrillation (POAF).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Elective isolated on-pump CABG surgery
- •Informed consent
Exclusion Criteria
- •Patients with a severe pulmonary disease
- •Patients with renal failure (GFR\<30 mL/min/1.73 m2)
- •Patients with liver failure
- •Peripheral vascular disease affecting the upper limbs
- •Patients on sulfonylurea derivatives.
- •Patients with atrial fibrillation in their case history
- •Prior cardiac surgery (Re-operations)
Outcomes
Primary Outcomes
Postoperative atrial fibrillation
Time Frame: Up to 10 days after surgery
A patient will be classified as belonging to the postoperative atrial fibrillation group if they have any episode of atrial fibrillation, measured by telemetry, lasting more than 1 minute during their postoperative days at the hospital.
Secondary Outcomes
- Length of hospital stay(Maximum 14 days)