Asphyxia at Birth : Evolution of Birth Asphyxia Rate, Etiologies and Neonatal Outcome From 2000 to 2016
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 61,448
- 试验地点
- 1
- 主要终点
- Rate of Neonatal asphyxia
研究概览
简要总结
This is an historic cohort study based on the birth and delivery register of the HFME maternity ward. This study aim at understanding the evolution of asphyxia at birth, at all gestational ages, identifying causes and describing neonatal outcomes since 2000, when a second line strategy for foetal surveillance (fetal ECG) and systematic umbilical acid-gas cord blood were introduced in our maternity ward.
The investigator's hypothesis was that the neonatal asphyxia decrease could be due to 3 main factors including second line strategy introduction, systematic umbilical cord acid-base implementation and improvement in antenatal risk factor screening for asphyxia. The investigator's second hypothesis was that neonatal prognosis in neonates with acidosis was improved with systematic early after birth EEG evaluation, allowing early treatment and surveillance.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 1 Hour(Child)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All births at the maternity ward of the hospital Femme-Mère-Enfant from 1st of january 2000 to 31 december 2016
排除标准
- •Infants born after medical pregnancy termination and born out of the hospital and secondarily hospitalized in our department will be excluded
结局指标
主要结局
Rate of Neonatal asphyxia
时间窗: 2 months
Neonatal asphyxia define as fetal death, neonatal death, NICU transfer, neonatal seizure, umbilical-artery blood pH ≤ 7.05 with a base deficit ≥ 12 mmol per liter, intubation for ventilation at delivery or neonatal encephalopathy
次要结局
未报告次要终点
