Neutropenic Fever, Inflammatory Markers and Sepsis in Haematological Patients
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 273
- Locations
- 1
- Primary Endpoint
- This study evaluates epidemiology, microbiology and outcome of neutropenic fever and severe sepsis in haematological patients with special reference to the kinetics of inflammatory markers.
Study Overview
Brief Summary
The aim of this study is to find out whether inflammation markers including cardiac markers have predictive value in evaluation of pathogenesis of sepsis in neutropenic haematological patients.
Detailed Description
Adult AML and ASCT patients with neutropenic fever. Observation of possible progress to severe sepsis or septic shock. Blood sample collection on days 0-3 (from the beginning of neutropenic fever).
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •diagnosis: acute myeloid leukaemia
- •age under 70 years
- •neutropenic fever
Exclusion Criteria
- •age above 70 years
- •no neutropenic fever
Outcomes
Primary Outcomes
This study evaluates epidemiology, microbiology and outcome of neutropenic fever and severe sepsis in haematological patients with special reference to the kinetics of inflammatory markers.
Time Frame: Within neutropenic period after treatment
This study evaluated epidemiology, microbiology and outcome of neutropenic fever and severe sepsis in haematological patients with special reference to the kinetics of specific inflammatory markers.
Secondary Outcomes
No secondary outcomes reported
Investigators
Sari Hamalainen
MD, PhD
Kuopio University Hospital