Effect of Vitamin D-biofortified Eggs on Wintertime Serum 25-hydroxyvitamin D in Adults: Randomized Controlled Trial
Not Applicable
Completed
- Conditions
- Vitamin D Deficiency
- Registration Number
- NCT02678364
- Lead Sponsor
- University College Cork
- Brief Summary
While there have been a considerable number of studies on the impact of additional vitamin D in the diets of hens on the resulting egg vitamin D content, the effect of consumption of such vitamin D-enhanced eggs on vitamin D status of healthy human subjects has not been tested in a RCT.
- Detailed Description
The aim of this study was to investigate the effect of consumption of vitamin D3 versus 25-hydroxyvitamin D3 biofortified eggs on winter serum 25(OH)D in adults using a 8-wk randomized controlled trial. This research will provide new data on the potential of vitamin D enriched eggs as a food-based strategy for prevention of vitamin D deficiency.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 55
Inclusion Criteria
- consenting white men and women aged 45-70 years
Exclusion Criteria
- consumption of vitamin D-containing supplements throughout the study. planning to take a winter vacation (during the course of the 8-wk intervention) - to a location at which either the altitude or the latitude would be predicted to result in significant cutaneous vitamin D synthesis from solar radiation
- planning to use tanning facilities of any type.
- a severe medical illness,
- allergy to egg products,
- medically advised to limit egg intake in relation to managing hypercholesterolemia,
- hypercalcaemia,
- known intestinal malabsorption syndrome,
- excessive alcohol use,
- the use of medications known to interfere with vitamin D metabolism
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Response of serum total 25-hydroxyvitamin D concentration over 8 weeks of winter up to 8 weeks
- Secondary Outcome Measures
Name Time Method Serum parathyroid hormone 0 weeks and 8 weeks
Trial Locations
- Locations (1)
Human Dietary Studies Facility, School of Food and Nutritional Sciences, University College Cork
🇮🇪Cork, Ireland
Human Dietary Studies Facility, School of Food and Nutritional Sciences, University College Cork🇮🇪Cork, Ireland