Testing the ability to reduce immunosuppression in older renal transplant recipients

Not Applicable

• Conditions: Kidney transplant recipients; Urological and Genital Diseases; Kidney transplantation

• Registration Number: ISRCTN15218460
• Lead Sponsor: niversity of London

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-09-29
• Last Update Posted: 10 October 2022
• Study Completion: 2027-07-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 106

Inclusion Criteria

1. First time adult recipients of either a deceased or living donor kidney transplant
2. Recipient of a single organ transplant only
3. Age above 60 years
4. Negative screen for donor-specific antibody prior to transplantation (MFI<2000)

Exclusion Criteria

1. Recipients that are highly sensitised (cRF >85%)
2. Inability to participate in frequent monitoring of renal transplant function and clinical visits (every 4 weeks) during dd-cfDNA monitoring and IS minimisation.
3. Immune-mediated renal disease in which IS minimisation is inadvisable
4. EBV IgG negative recipient (as IS minimisation is part of standard protocol)
5. Inability to comply with study directed treatment

Study & Design

• Study Type: Interventional
• Study Design: Not specified