Deproteinized bovine bone and freeze-dried bone allograft in sinus floor augmentatio

Phase 4

Completed

• Conditions: patients who required upper posterior implant placement; bone grafting; implant

• Registration Number: TCTR20221217002
• Lead Sponsor: Faculty of Dentistry, Chulalongkorn University

Brief Summary

Two-stage maxillary sinus augmentation with FDBA upregulated specific bone remodeling genes when compared to DBB. The outcome of gene expression matched with the ones for OPN immunoreactivity, being higher in the FDBA group. FDBA had an expression pattern similar to native bone and also showed stronger expression of bone forming related genes which preferred clinically when compared to DBB.

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-04-30
• Study Start: 2022-12-17
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

Patients who required upper posterior
implant placement

Exclusion Criteria

Individuals with bone-related diseases such as osteoporosis, disorders of bone mineral homeostasis or risk factors that affect bone healing such as uncontrolled diabetes, steroid therapy, excessive smoking, improper oral hygiene were excluded

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gene expression of Runx2, Opn, Ocn, Col1a1, Rankl and Tnf 6months real-time polymerase chain reaction

Secondary Outcome Measures

Name	Time	Method
Bone characteristics 6months histology, immunohistochemistry