Establishment of Accurate Diagnosis and Treatment System for Postoperative Chronic Pain Based on Functional Magnetic Resonance Imaging
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- different fMRI results of specific brain regions between people with and without chronic pain
研究概览
简要总结
Postoperative pain is an ideal model for study on acute pain changing into chronic pain. The functional imaging of magnetic resonance can reflect the extent and character of pain exactly and the structural imaging of it can be a sign of the change. By analyzing fMRI results of participants with acute pain and following them up for three months, the investigators expect to find objective indicators for acute pain changing into chronic pain and give preventive analgesia for people with high risk of chronic pain.
详细描述
The day before surgery, evaluate and choose patients according to inclusion and exclusion criteria. Use the same anaesthesia and management and record information needed by the case report format. Patients are examined by fMRI on their brains during the first week after surgery. Follow up the patients after surgery for three months to find out whether they have chronic pain. The NRS, DN4, ID pain and QLQ-C30 are used for each patient.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •junior high school degree or above
- •can be communicated in mandarin normally
- •selective operation of mastectomy with or without axillary lymph node dissection
- •similar operation method and incision size
- •BMI between 18 and 30
- •ASA grade I-II；informed consent
排除标准
- •with brain disease or with brain disease history
- •Opioid allergy
- •with claustrophobia
- •with history of chronic pain
- •with psychological or emotional problems
- •Serious hearing or visual impairment
- •those who refuse to participant in this study
结局指标
主要结局
different fMRI results of specific brain regions between people with and without chronic pain
时间窗: in the first week after surgery
amplitude of low frequency fluctuation(ALFF) and regional homogeneity(ReHo) of related brain regions
次要结局
- the incidence of chronic pain after mastectomy(six months after surgery)
- the quality of life in patients after mastectomy(six months after surgery)