Assessment of the efficacy of a 6-weeks randomized, controlled half-facetreatment with topical formulae containing P798208 08 compared to itsplacebo in healthy volunteers with oily skin.

The study will be monocentric, comparative, placebo controlled, double-blinded and randomized half-face application out patient study. The study objectives are (1) To assess the efficacy of a compound on oily skin as determined by clinical and instrumental evaluations measuring the amount of sebum and its effect on acne formation and (2) to assess the safety and local tolerance of a formulae containing P798208 08 in facial cosmetic products. The study rationale is to evaluate the effect of a mix of essential oils (P798208 08) containing mostly lemongrass and rosemary essential oils. This active mix is expected to reduce p.acnes, inflammation and stimulate the exfoliation process that will reduce sebum secretion and acne formation. Topical application (on the face) will be done once a day on dried skin from study days D1 to D42. The subjects will receive a topical gel containing P798208 08 on one half face, and corresponding vehicle on the other half of the face according to a pre-determined randomization list. The subject study period is 6 weeks and study duration is 8 weeks. The study will be conducted in healthy human male volunteers (age 18-40 yrs) with oily skin. Thirty seven subjects will be enrolled to ensure that at least thirty two randomized subjects complete the study procedures.