Cardiac T1 Mapping Enables Risk Prediction of LV Dysfunction After Surgery for Aortic Regurgitation
Completed
- Conditions
- Aortic Regurgitation
- Interventions
- Procedure: aortic valve surgery
- Registration Number
- NCT05332184
- Lead Sponsor
- Universitätsklinikum Hamburg-Eppendorf
- Brief Summary
To assess whether cardiac T1 mapping for detection of myocardial fibrosis enables preoperative identification of patients at risk for early left ventricular dysfunction after surgery of aortic regurgitation.
- Detailed Description
We hypothesized that a diffuse interstitial myocardial fibrosis may be present in AR patients who experience early systolic LV dysfunction after aortic valve surgery. We aimed to evaluate the association between preoperative cardiac T1 mapping for detection of myocardial fibrosis and early systolic LV dysfunction after surgery for aortic regurgitation.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Consecutive patients with severe aortic regurgitation referred for aortic valve surgery were prospectively enrolled in the study.
Exclusion Criteria
- history of coronary artery disease
- acute aortic valve disease (i.e., type A aortic dissection or infectious endocarditis)
- common contraindications for MRI such as severe obesity and metallic foreign bodies.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients prior to aortic valve surgery aortic valve surgery -
- Primary Outcome Measures
Name Time Method Native T1 baseline (Prior surgery) Measured with MRI
- Secondary Outcome Measures
Name Time Method