NCT01346904UnknownNot Applicable
The Central Nerve System Injury in Patients With Primary Open Angle Glaucoma
Huazhong University of Science and Technology0 sites200 target enrollmentStarted: May 2011Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 200
Study Overview
Brief Summary
Glaucomatous damage not only occurred to retinal ganglion cells in the eyes, but went across optic nerves, visual chiasm, lateral geniculate nucleus (LGN) and finally the visual cortex; the neural degenerations could be identified through the whole visual tract, which suggests the central nerve system may play a vital role in the progression of glaucoma. The investigators used MRI to investigate changes of visual pathway in vivo.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Primary open angle glaucoma diagnosed on the basis of glaucomatous optic disc cupping ratio (in particular, thinning of the inferior and/or superior rim, cup-to-disc ratio asymmetry of >0.2)
- •matching glaucomatous visual field defects (European Glaucoma Society (2008) Perimetry )
Exclusion Criteria
- •optic neuropathy
- •neurological disorder
- •other diseases and use of systemic medications which affect optic nerve or the visual field underwent complete eye examination and visual-field testing.
Investigators
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