Neural Mechanisms of Motor Recovery With Technology Assisted Training
- Conditions
- HemiparesisStroke Sequelae
- Registration Number
- NCT05560867
- Lead Sponsor
- University of Maryland, Baltimore
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Terminated
- Sex
- All
- Target Recruitment
- 4
Inclusion Criteria:<br><br> - Age 18 to 88 years<br><br> - Able to provide informed consent based on Evaluation to Sign Informed Consent.<br><br> - History of clinically defined, unilateral hemiparetic stroke, with radiologic<br> exclusion of other possible diagnosis, causing weakness in 1 arm 6 months or more<br> prior to enrollment.<br><br> - Fugl-Meyer upper extremity score <= 50 at time of enrollment<br><br> - Medically stable to participate in the study and have mobility, visual, and<br> cognitive abilities sufficient to follow directions and engage in the gamified<br> therapeutic tasks.<br><br>Exclusion Criteria:<br><br> - Undergoing any significant medical treatments requiring regular visits, treatments,<br> or therapies at the time of enrollment or anytime during the study.<br><br> - Hair or scalp implant that would not allow near infrared spectroscopy probes to sit<br> on scalp.<br><br> - Injection of botulinum toxin to the paretic arm within 3 months of enrollment or<br> during the study or injection of daxibotulinumtoxinA within 6 months of enrollment<br> or during the study<br><br> - Orthopedic, rheumatologic, or other medical disease that would make the procedures<br> of participation dangerous, painful, or uncomfortable.<br><br> - Contraindications to MRI, including intracranial magnetic items, implanted pumps,<br> pacemakers, or stimulators, or claustrophobia.
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in cortical connectivity measures as assessed using MRI;Changes in cortical connectivity measures as assessed using fNIRS
- Secondary Outcome Measures
Name Time Method Changes in NIH Stroke Scale Score (NIHSS);Changes in Stroke Impact Scale (SIS);Changes in arm kinematics (position);Changes in arm kinematics (velocity);Changes in arm kinematics (acceleration);Changes in Fugl-Myer Scores for the Upper Extremity (FM-UE);Changes in Action Research Arm Test;Changes in Wolf Motor Function Test (WMFT);Changes in Shoulder Abduction Finger Extension (SAFE) score