Persistence of Humoral and Cellular Immune Responses Following Age-appropriate Vaccination With the MMR Vaccine
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 74
- 试验地点
- 1
- 主要终点
- Levels of mumps antibody and levels of memory B and T cell responses
研究概览
简要总结
This study will lay the foundation for determining the underlying reasons for lack of immunity to mumps that led to the 2006 mumps outbreak on college campuses in the Mid West, and it will assess the potential for similar outbreaks of measles and rubella. A total of 70 to 80 college students (age 18 to 22) on the Emory campus (or nearby college campuses or the community) will be assessed for antibodies to measles, mumps or rubella by drawing a one-time blood sample. Their medical records will be verified for documentation of immunization with MMR vaccine prior to enrollment in the study. If a study volunteer is found to not have MMR immunity, they will be offered an MMR-II vaccine. For this group, additional blood specimens will be obtained.
详细描述
No additional description needed.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 24 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ability and willing to provide an informed consent
- •Documented receipt of MMR-II vaccination in childhood
- •Not pregnant
- •Exclusion Criteria
- •No history of HIV infection.
- •Immunocompromised health status due to HIV infection, cancer, diabetes, liver, lung or kidney diseases, autoimmune diseases, history of splenectomy.
- •Use of immunosuppressive medications within last 2 to 3 months (oral or parenteral corticosteroids or cytotoxic medications)
- •Medical conditions that require the use of immunosuppressive medications
- •Received blood or blood products within the last 30 days
- •Any vaccines received in the last 30 days
排除标准
- 未提供
结局指标
主要结局
Levels of mumps antibody and levels of memory B and T cell responses
时间窗: Day 1 for all participants except for those who receive MMR vaccine, there will be additional outcome measures on Day 0, 7, 14 and 28 post-vaccination.
Cross sectional measurement of antibodies to mumps. measles or rubella
次要结局
- Determine proportion of college-aged students who are seronegative for mumps(outcome measurement on Day 1)
研究者
Sri Edupuganti, MD MPH
Assistant Prfessor
Emory University