Measles, Mumps, and Rubella (MMR) Immunity in College Students

Completed

• Conditions: Mumps; Measles; Rubella
• Interventions: Biological: MMR vaccine

• Registration Number: NCT00962819
• Lead Sponsor: Sri Edupuganti, MD MPH

Brief Summary

This study will lay the foundation for determining the underlying reasons for lack of immunity to mumps that led to the 2006 mumps outbreak on college campuses in the Mid West, and it will assess the potential for similar outbreaks of measles and rubella. A total of 70 to 80 college students (age 18 to 22) on the Emory campus (or nearby college campuses or the community) will be assessed for antibodies to measles, mumps or rubella by drawing a one-time blood sample. Their medical records will be verified for documentation of immunization with MMR vaccine prior to enrollment in the study. If a study volunteer is found to not have MMR immunity, they will be offered an MMR-II vaccine. For this group, additional blood specimens will be obtained.

Detailed Description

No additional description needed.

Study Timeline

• Study First Submitted: 2008-05-19
• Study First Submitted QC: 2009-08-19
• Study First Posted: 2009-08-20
• Study Start: 2010-03
• Primary Completion: 2012-12
• Study Completion: 2012-12
• Status Verified: 2021-10
• Last Update Submitted: 2021-10-01
• Last Update Posted: 2021-10-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

• Ability and willing to provide an informed consent
• Documented receipt of MMR-II vaccination in childhood
• Not pregnant

Exclusion Criteria

• No history of HIV infection.
• Immunocompromised health status due to HIV infection, cancer, diabetes, liver, lung or kidney diseases, autoimmune diseases, history of splenectomy.
• Use of immunosuppressive medications within last 2 to 3 months (oral or parenteral corticosteroids or cytotoxic medications)
• Medical conditions that require the use of immunosuppressive medications
• Received blood or blood products within the last 30 days
• Any vaccines received in the last 30 days

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
cross-sectional	MMR vaccine	College-aged students who were immunized with MMR.

Primary Outcome Measures

Name	Time	Method
Levels of mumps antibody and levels of memory B and T cell responses	Day 1 for all participants except for those who receive MMR vaccine, there will be additional outcome measures on Day 0, 7, 14 and 28 post-vaccination.	Cross sectional measurement of antibodies to mumps. measles or rubella

Secondary Outcome Measures

Name	Time	Method
Determine proportion of college-aged students who are seronegative for mumps	outcome measurement on Day 1	Cross-sectional measurement of antibodies to mumps, measles and rubella

Trial Locations

Locations (1)

The Hope Clinic of the Emory Vaccine Center; 🇺🇸 Decatur, Georgia, United States