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Clinical Trials/NCT07139158
NCT07139158CompletedNot Applicable

Quadriceps Muscle Oxygenation During Different Lower Limb Tasks in Patients With Patellofemoral Pain: A Cross-Sectional Study

Ankara Medipol University1 site in 1 country41 target enrollmentStarted: August 20, 2025Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
41
Locations
1
Primary Endpoint
Muscle Oxygenation

Study Overview

Brief Summary

Patellofemoral joint problems account for a significant portion of knee pain and disability. Among these problems, patellofemoral pain is not directly related to any obvious structural abnormality and is characterized by pain in the retro- or peri-patellar region, particularly during activities such as squatting, running, and climbing stairs. It is commonly seen in the general population. The current literature highlights the tendency of patellofemoral pain to recur and become chronic despite all treatments. Individuals with patellofemoral pain often experience disorders in the neuromuscular function of the quadriceps femoris muscle, which is necessary for knee function and dynamic stability and is frequently suggested to play an important role in the pathophysiology of the disease. A decrease in the tissue's ability to utilize oxygen during exercise or physical activity may lead to permanent dysfunction of the quadriceps femoris muscle. However, no studies have been found in the literature examining changes in oxygenation of the quadriceps femoris muscle in individuals with patellofemoral pain. Therefore, the aim of this study is to investigate changes in oxygenation of the quadriceps femoris muscle in individuals with patellofemoral pain during various exercises and physical activities by comparing them with pain-free individuals.

Study Design

Study Type
Observational
Observational Model
Other
Time Perspective
Cross Sectional

Eligibility Criteria

Ages
18 Years to 40 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •18-40 years of age
  • •pain around or behind the patella, which is aggravated by at least one activity that loads the patellofemoral joint during weight bearing on a flexed knee (e.g., squatting, stair ambulation, jogging/running, hopping/jumping)
  • •the pain persist for at least four months, and be rated at ≥ 3/10 on the Numeric Pain Rating Scale (NPRS)
  • •vastus medialis muscle adipose tissue thickness <20 mm
  • •Pain-free controls were age- and gender-matched, with vastus medialis muscle adipose tissue thickness <20 mm.

Exclusion Criteria

  • •a history of joint surgery
  • •meniscal and/or ligament injuries
  • •patellar instability, congenital patellar subluxation/dislocation
  • •any cardiovascular, congenital, or musculoskeletal disorders that could interfere with the assessment

Arms & Interventions

Patellofemoral Pain Group

Pain-free Control Group

Outcomes

Primary Outcomes

Muscle Oxygenation

Time Frame: Day 1

Vastus medialis muscle oxygenation will be evaluated with Near-Infrared Spectroscopy at rest, during and after activity.

Secondary Outcomes

  • Kujala Patellofemoral Score Scale(Day 1)
  • Adipose tissue thickness(Day 1)
  • International Physical Activity Questionnaire (IPAQ)(Day 1)
  • Numeric Pain Rating Scale(Day 1)
  • Tampa Kinesiophobia Scale(Day 1)

Investigators

Sponsor
Ankara Medipol University
Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Selcan Suicmez

Research Assistant

Ankara Medipol University

Study Sites (1)

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