Analysis of Odontogenic Keratocyst Treated With Various Modalities Over a 10-year
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Qassim University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Measurement of the bony cavity
Study Overview
Brief Summary
Background The odontogenic keratocysts (OKCs) have been one of the maxillofacial region's most contentious pathological phenomena. Decompression/marsupialization (D/M), enucleation (E), enucleation + chemical cauterization with Carnoy's solution (E+CS), enucleation + peripheral ostectomy (E + PO), as opposed to enucleation + chemical cauterization with Carnoy's solution + peripheral ostectomy (E + CS + PO), were used during surgery to ensure that no epithelial remnants were left behind.
Rationale Through the management of OKC a recurrence could occur, the effectiveness of Decompression/marsupialization (D/M), Enucleation (E), Enucleation+Carnoy's solution chemical cauterization (E+CS), Enucleation+peripheral ostectomy (E+PO), Enucleation+Carnoy's solution chemical cauterization + peripheral ostectomy (E+CS + PO), will be analyzed
Detailed Description
Since the middle of the 20th century, the odontogenic keratocyst (OKC) has been one of the maxillofacial region's most contentious pathological phenomena. It was initially misdiagnosed as a primordial cyst. After that, because of its severe clinical behavior and tendency to recur, it was no longer considered to be a part of its classification, also known as a odontogenic tumor. Then, In 2017, the OKC are re-classified as a cystic lesion. But still there is debate about their management. So, this study will be enrolled with the following objectives: to describe how odontogenic keratocysts are managed, to Discover the most favorable approach to manage OKC with the need to stop it from happening again To categorize the odontogenic keratocyst management outcomes into to the subsequent groups: (1) total resolution, (2) partial resolution; (3) Recurrence.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Masking Description
The patients, investigators, and outcomes assessor will not be informed about the study
Eligibility Criteria
- Ages
- 10 Years to — (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •All odontogenic keratocysts that are treated by the following surgical treatment modalities:
- •Enucleation followed by peripheral ostectomy and Carnoy's solution
- •Decompression/ marsupialization
- •Enucleation
- •Enucleation and Carnoy's solution
- •Enucleation and Peripheral Ostectomy
- •Follow-up period 10 years
Exclusion Criteria
- •Cases treated with resection
- •Cases showed neoplastic transformation in their pathology
- •Cyst Like lesions
Arms & Interventions
Enucleation + Peripheral ostectomy + Carnoy's solution chemical cauterization (E+ PO+ CS)
The odontogenic keratocysts will be treated using enucleation, followed by peripheral ostectomy and then Carnoy's solution
Intervention: Enucleation+ Peripheral Ostectomy+Carnoy's solution chemical cauterization (E+CS + PO) (Procedure)
Decompression/marsupialization (D/M)
The odontogenic keratocysts will be managed by either Decompression or marsupialization
Intervention: Decompression/ marsupialization (D/M) (Procedure)
Enucleation (E)
The odontogenic keratocysts will only be managed by Enucleation (E)
Intervention: Enucleation (E) (Procedure)
Enucleation+Carnoy's solution (E+CS)
odontogenic keratocysts will be managed by Enucleation, followed by Carnoy's solution
Intervention: Enucleation+Carnoy's solution (E+CS) (Procedure)
Enucleation+ Peripheral Ostectomy (E+PO)
The odontogenic keratocysts will be treated using Enucleation, followed by peripheral ostectomy (E+PO)
Intervention: Enucleation+ Peripheral Ostectomy (E+ PO) (Procedure)
Outcomes
Primary Outcomes
Measurement of the bony cavity
Time Frame: At the end of the postoperative ninth month
A presence of radiolucent area in the computed tomography scans
Recurrence rate
Time Frame: At the end of the postoperative tenth year
The new occurrence of the previously removed odontogenic keratocyst will be documented
Healing period
Time Frame: Starting from the postoperative third month up to the postoperative ninth month
The bone filling will monitored by using computed tomography scans
Recurrence rate
Time Frame: At the end of the postoperative fifth year
The new occurrence of the previously removed odontogenic keratocyst will be documented
Secondary Outcomes
No secondary outcomes reported
Investigators
Ghada Amin Khalifa, PhD
Professor of Maxillofacial Surgery and Diagnostic Science
Qassim University