Different Modalities of Management of Odontogenic Keratocysts

Not Applicable

Recruiting

• Conditions: Odontogenic Cysts
• Interventions: Procedure: Enucleation+Carnoy's solution (E+CS); Procedure: Decompression/ marsupialization (D/M); Procedure: Enucleation+ Peripheral Ostectomy (E+ PO); Procedure: Enucleation+ Peripheral Ostectomy+Carnoy's solution chemical cauterization (E+CS + PO); Procedure: Enucleation (E)

• Registration Number: NCT06133764
• Lead Sponsor: Qassim University

Brief Summary

Background The odontogenic keratocysts (OKCs) have been one of the maxillofacial region's most contentious pathological phenomena. Decompression/marsupialization (D/M), enucleation (E), enucleation + chemical cauterization with Carnoy's solution (E+CS), enucleation + peripheral ostectomy (E + PO), as opposed to enucleation + chemical cauterization with Carnoy's solution + peripheral ostectomy (E + CS + PO), were used during surgery to ensure that no epithelial remnants were left behind.

Rationale Through the management of OKC a recurrence could occur, the effectiveness of Decompression/marsupialization (D/M), Enucleation (E), Enucleation+Carnoy's solution chemical cauterization (E+CS), Enucleation+peripheral ostectomy (E+PO), Enucleation+Carnoy's solution chemical cauterization + peripheral ostectomy (E+CS + PO), will be analyzed

Detailed Description

Since the middle of the 20th century, the odontogenic keratocyst (OKC) has been one of the maxillofacial region's most contentious pathological phenomena. It was initially misdiagnosed as a primordial cyst. After that, because of its severe clinical behavior and tendency to recur, it was no longer considered to be a part of its classification, also known as a odontogenic tumor. Then, In 2017, the OKC are re-classified as a cystic lesion. But still there is debate about their management. So, this study will be enrolled with the following objectives: to describe how odontogenic keratocysts are managed, to Discover the most favorable approach to manage OKC with the need to stop it from happening again To categorize the odontogenic keratocyst management outcomes into to the subsequent groups: (1) total resolution, (2) partial resolution; (3) Recurrence.

Study Timeline

• Study Start: 2023-02-24
• Study First Submitted: 2023-11-08
• Study First Submitted QC: 2023-11-13
• Study First Posted: 2023-11-15
• Status Verified: 2024-08
• Last Update Submitted: 2025-04-09
• Last Update Posted: 2025-04-13
• Primary Completion: 2025-12-31
• Study Completion: 2026-01-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• All odontogenic keratocysts that are treated by the following surgical treatment modalities:

  1. Enucleation followed by peripheral ostectomy and Carnoy's solution
  2. Decompression/ marsupialization
  3. Enucleation
  4. Enucleation and Carnoy's solution
  5. Enucleation and Peripheral Ostectomy

• Follow-up period 10 years

Exclusion Criteria

• Cases treated with resection
• Cases showed neoplastic transformation in their pathology
• Cyst Like lesions

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Enucleation+Carnoy's solution (E+CS)	Enucleation+Carnoy's solution (E+CS)	odontogenic keratocysts will be managed by Enucleation, followed by Carnoy's solution
Decompression/marsupialization (D/M)	Decompression/ marsupialization (D/M)	The odontogenic keratocysts will be managed by either Decompression or marsupialization
Enucleation+ Peripheral Ostectomy (E+PO)	Enucleation+ Peripheral Ostectomy (E+ PO)	The odontogenic keratocysts will be treated using Enucleation, followed by peripheral ostectomy (E+PO)
Enucleation + Peripheral ostectomy + Carnoy's solution chemical cauterization (E+ PO+ CS)	Enucleation+ Peripheral Ostectomy+Carnoy's solution chemical cauterization (E+CS + PO)	The odontogenic keratocysts will be treated using enucleation, followed by peripheral ostectomy and then Carnoy's solution
Enucleation (E)	Enucleation (E)	The odontogenic keratocysts will only be managed by Enucleation (E)

Primary Outcome Measures

Name	Time	Method
Measurement of the bony cavity	At the end of the postoperative ninth month	A presence of radiolucent area in the computed tomography scans
Recurrence rate	At the end of the postoperative tenth year	The new occurrence of the previously removed odontogenic keratocyst will be documented
Healing period	Starting from the postoperative third month up to the postoperative ninth month	The bone filling will monitored by using computed tomography scans

Trial Locations

Locations (1)

College of Dentistry, Qassim University; 🇸🇦 Buraydah, Qassim Region, Saudi Arabia