Health-related Quality of Life and Comorbidities in Danish Patients With Idiopathic Pulmonary Fibrosis - a Nationwide Follow-up
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Idiopathic Pulmonary Fibrosis
- Sponsor
- Aarhus University Hospital
- Enrollment
- 150
- Locations
- 3
- Primary Endpoint
- Health-related quality of life
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a high mortality. Health-related quality of life (HRQL) is impaired in patients with IPF. Little is known about the properties of recently developed HRQL questionnaires and about the longitudinal changes in HRQL, including factors with an impact on HRQL. Comorbidities have an impact on patients with IPF, but reports differ in incidence and prevalence. The impact of comorbidities on HRQL and disease progression has only been studied sparsely. Also, the association between biomarkers and disease progression need to be examined further.
Investigators
Eligibility Criteria
Inclusion Criteria
- •A clinical diagnosis of IPF
- •Signed informed consent
Exclusion Criteria
- •Clinical, radiological or histological findings inconsistent with a diagnosis of IPF
- •Inability or unwillingness to adhere to the study
- •Active on lung transplantation list
Outcomes
Primary Outcomes
Health-related quality of life
Time Frame: Baseline, 2 weeks, 6 months, 12 months, 24 months, 36 months
Changes in King's Brief Interstitial Lung Disease questionnaire
Number and type of comorbidities
Time Frame: Change/incidence at 6 months, 12 months, 24 months and 36 months
Incidence of new comorbidities after 6 months, 12 months, 24 months and 36 months
Secondary Outcomes
- Lung function tests(Baseline, 6 months, 12 months, 24 months, 36 months)
- Disease progression(Baseline, 6 months, 12 months, 24 months, 36 months)
- 6-minute walk test(Baseline, 6 months, 12 months, 24 months, 36 months)
- Progression in serum/plasma biomarker levels(Baseline, 6 months, 12 months, 24 months, 36 months)
- Health-related quality of life(Baseline, 6 months, 12 months, 24 months, 36 months)