Dynamic Hyperinflation During Maximal Voluntary Ventilation in Healthy Subjects
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 45
- 试验地点
- 2
- 主要终点
- Frequency which induces Dynamic Hyperinflation
研究概览
简要总结
Maximal Voluntary Ventilation (MVV) correlates well with maximal exercise capacity and is used to assess the ventilatory function during exercise in COPD (Chronic Obstructive Pulmonary Disease) patients. Dynamic hyperinflation (DH) often occurs during MVV in COPD and is believed to be due to expiratory flow limitation.
The present study is intended to assess whether DH can also occur during MVV in normal subjects without expiratory flow limitation.
详细描述
Maximal voluntary ventilation (MVV) correlates well with maximal exercise capacity and is used to assess the ventilatory function during exercise in COPD (Chronic Obstructive Pulmonary Disease) patients. Dynamic hyperinflation (DH) often occurs during MVV in COPD and is believed to be due to expiratory flow limitation. The present study is intended to assess whether DH can also occur during MVV in normal subjects without expiratory flow limitation.
Study design: healthy subjects with normal lung function will perform MVV at increasing breathing frequencies and maximal tidal volume, from 10 to 100 cycles per minute. Inspiratory capacity (IC) will be measured at rest and after each 12 seconds of MVV in order to detect DH. From the moment DH appeares at a given frequency, only one additional MVV at a higher breathing frequency will be conducted to confirm DH.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects
排除标准
- •History of asthma, obstructive syndrome on basic lung function
结局指标
主要结局
Frequency which induces Dynamic Hyperinflation
时间窗: day one
We analyze Frequency of Maximal Voluntary Ventilation (MVV) which induces a significant decrease of the Inspiratory Capacity (IC) post MVV compared to the IC at rest.
次要结局
- Correlation between the frequency which induces Dynamic Hyperinflation (DH) and Forced Vital Capacity(day one)
- Correlation between the frequency which induces Dynamic Hyperinflation (DH) and IC/FVC ratio (IC : Inspiratory Capacity at rest ; FVC : Forced Vital Capacity)(day one)
- Correlation between the frequency which induces Dynamic Hyperinflation (DH) and Forced Expiratory Volume in one second(day one)
- Correlation between the frequency which induces Dynamic Hyperinflation (DH) and body mass index(day one)
- Correlation between the frequency which induces Dynamic Hyperinflation (DH) and age(day one)
- Correlation between the frequency which induces Dynamic Hyperinflation (DH) and Forced Expiratory Flows at 25%, 50% and 75% of Forced Vital Capacity(day one)
- Comparison Maximal Voluntary Ventilation with Forced Expiratory Volume in one second multiplied by 35(day one)
- Correlation between the frequency which induces Dynamic Hyperinflation (DH) and Inspiratory Capacity at rest(day one)