High disease activity and prednisone use during pregnancy; lifelong consequences for children of mothers with rheumatoid arthritis?
Completed
- Conditions
- chronicsystemic inflammatory disorder1001842410028920
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 378
Inclusion Criteria
mother has participated in the PARA study (MEC 214.320/2002/117)
Exclusion Criteria
a) twins
b) non-Caucasian children
c) children with congenital abnormalities
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Anthropometric data of the child<br /><br>- Height<br /><br>- Weight<br /><br>- Sitting height<br /><br>- Head circumference<br /><br>- Arm/waist/hip circumference<br /><br><br /><br>Blood pressure of the child<br /><br>- 3 times measurement on one day<br /><br><br /><br>Parents:<br /><br>- weight<br /><br>- height<br /><br>- head circumference<br /><br>- blood pressure<br /><br><br /><br>Information on:<br /><br>- Familiy medical hisory<br /><br>- Medication use of mother<br /><br>- Growth chart from birth onwards</p><br>
- Secondary Outcome Measures
Name Time Method <p>Data on body composition & fat percentage<br /><br>- Lean body mass<br /><br>- Holtain skin fold caliper<br /><br>- Abdominal ultrasound<br /><br>- Dual Energy X-ray Absorptiometry (DXA)<br /><br><br /><br>Venapuncture<br /><br>- glucose<br /><br>- glucose fasting levels<br /><br>- C-peptide<br /><br>- Insulin<br /><br>- Cortisol<br /><br>- Total cholesterol<br /><br>- HDL<br /><br>- LDL<br /><br>- Triglycerides<br /><br>- Free fatty acid<br /><br>- Adiponectin<br /><br>- DNA analysis (genetic variation and epigenetic changes)<br /><br><br /><br>24 h cortisol levels in saliva<br /><br>- 4 measurements on one day<br /><br><br /><br>Buccal epithelial cells obtained by mouth swab<br /><br>- DNA analysis, 1 measurement</p><br>