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临床试验/NCT00204971
NCT00204971已完成4 期

Randomized, Placebo-controlled Clinical Trial of Enteral Glutamine Supplementation in Neurologically-injured Patients

University of Wisconsin, Madison2 个研究点 分布在 1 个国家目标入组 102 人开始时间: 2003年1月最近更新:
适应症

试验速览

阶段
4 期
状态
已完成
入组人数
102
试验地点
2
主要终点
Nosocomial infections

研究概览

简要总结

Nutrition is an important part of the recovery process after having a head injury so that subjects can gain strength and fight off infection. Liquid nutrition formulas are often given to patients through a tube that has been placed into the intestines for feeding when they are unable to eat on their own. Some reports suggest that nutrition with extra amounts of the amino acid called glutamine may decrease infections and hospital stay in severely injured patients.The purpose of this study is to evaluate if giving extra amounts of an amino acid called glutamine with liquid nutrition formulas will decrease the risk of infection and length of stay in the intensive care unit after having a head injury.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Factorial
主要目的
Prevention
盲法
Double (Participant, Investigator)

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Nonpregnant females
  • Aged 18-75 years old
  • Glasgow Coma Scores of 3-12
  • Injury Severity Scores greater than or equal to 20
  • Requiring enteral nutrition for a minimum of 5 days

排除标准

  • Documented hepatic dysfunction
  • Acute renal failure (creatinine clearance < 15 mL/min)
  • Gastrointestinal malabsorptive disorder
  • Infection at time of admission

结局指标

主要结局

Nosocomial infections

时间窗: throughout study

次要结局

  • Multiple organ dysfunction syndrome(throughout the study)
  • Nutritional outcome parameters(throughout the study)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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