KNEE AI (Knee NEEdle Aspiration for Infection) Trial:Serial knee aspirations for the treatment of native septic arthritis in adults. Single Arm Phase II trial

Informed consent to participate in the trial

Patient demographic data (Age, sex, knee side). Age 18yrs and above

Patients’ comorbid

Pre-aspiration data (Knee pain, swelling, redness, ROM actively and passively, WOMAC, VAS score, Inflammatory marker, Counts, Gram Stain and Culture results, Antibiotic if initiated before or after antibiotics)

Repeat labs every 48 hours by CBC and CRP

Repeat aspiration every clinical recollection noted and/or patient worsening in clinical/laboratory markers

Max aspirations are 3 times, then label as failed and proceed to standard washout

F/u 2 weeks, 3 months, and 6 months. Each with VAS and WOMAC functional scores

Infected prosthetic joints

Adjacent osteomyelitis preceding joint infection

Septic arthritis occurs as an incidental event late in the course of an otherwise fatal illness

Patients that are 17 years old or less

Reactive or Inflammatory arthritis

Polyarticular joint involvement

Symptoms more than 1 week