Molecular Epidemiology of Biliary Tree Cancers
概览
- 阶段
- 不适用
- 干预措施
- Biospecimen Collection
- 疾病 / 适应症
- Cholangiocarcinoma
- 发起方
- M.D. Anderson Cancer Center
- 入组人数
- 1500
- 试验地点
- 1
- 主要终点
- Significant factors that may contribute to the etiology of biliary tree cancer
- 状态
- 招募中
- 最后更新
- 15天前
概览
简要总结
This study is to learn if certain risk factors (environmental, viral, behavioral, medical, and dietary), tumor markers, and genetic changes can predict the development and outcome of biliary tree cancers. Establishing biomarkers models from patients may help doctors to further understand how biliary tree cancer is affected by different treatments, and why some people's cancer responds differently than others.
详细描述
PRIMARY OBJECTIVES: I. To identify significant factors that may contribute to the etiology of biliary tree cancer. II. To identify novel genetic loci that predispose to gallbladder cancers (GBC) and cholangiocarcinoma (CGC) diagnosis. EXPLORATORY AND CORRELATIVE OBJECTIVES: I. To use the collected blood and tissue materials for exploratory analysis to identify markers that predict prognosis of biliary tree cancers. II. To correlate the identified markers with results of specific aim I and II to test the interaction between the identified markers with environmental and genetic factors. OUTLINE: Participants complete a questionnaire over 20 minutes. Participants also undergo collection of blood and leftover tissue samples.
研究者
入排标准
入选标准
- •Pathologically or radiologically confirmed diagnosis of CGC or GBC
- •With or without prior radiation or chemotherapy
- •All United States of America (USA) and non USA residents
- •No age, gender, or racial restriction
- •Healthy control with no current or history of cancer
- •Healthy controls are USA and non USA residents
- •Healthy controls are matched to the cases in age (5 years), gender, and race
- •Healthy controls are friends and spouses of patients with other than gastro-intestinal (GI) cancers
- •Chronic Liver Disease (CLD) controls with no current or history of cancer
- •CLD controls are USA and non USA residents
排除标准
- 未提供
研究组 & 干预措施
Observational (biospecimen collection, questionnaire)
Participants complete a questionnaire over 20 minutes. Participants also undergo collection of blood and leftover tissue samples.
干预措施: Biospecimen Collection
Observational (biospecimen collection, questionnaire)
Participants complete a questionnaire over 20 minutes. Participants also undergo collection of blood and leftover tissue samples.
干预措施: Questionnaire Administration
结局指标
主要结局
Significant factors that may contribute to the etiology of biliary tree cancer
时间窗: through study completion, an average of 1 year