Effectiveness of Luliconazole Cream Versus Ciclopirox Olamine Cream in the Management of Localized Cutaneous Dermatophytosis: A Randomized Control Trail

This study is a randomized controlled trial designed to compare the clinical effectiveness and safety of two topical antifungal creams, luliconazole 1 percent and ciclopirox olamine 1 percent, in patients with localized cutaneous dermatophytosis. The research was conducted at Saveetha Medical College and Hospital in Tamil Nadu, India. A total of 40 patients were randomly assigned to two groups, with 20 patients receiving ciclopirox olamine and 20 patients receiving luliconazole. Both medications were applied twice daily for a period of 4 weeks.

Patients were evaluated at the start and end of the treatment based on a composite clinical score that measured itching, redness, skin thickening, and scaling. A mycological cure was confirmed using a potassium hydroxide mount examination. The results showed that both treatments led to significant clinical improvement. However, patients in the ciclopirox olamine group achieved lower mean clinical scores, indicating slightly better resolution of symptoms like redness and itching. Luliconazole showed high efficacy in reducing skin thickening. Both drugs were found to be safe and effective first line options for managing localized fungal skin infections in the current clinical setting