MedPath

Metformin/Rosuvastatin Combination Therapy With in Patients With Type 2 Diabetes and Dyslipidemia

Phase 3
Completed
Conditions
Type 2 Diabetes
Dyslipidemia
Interventions
Registration Number
NCT02827903
Lead Sponsor
Jeil Pharmaceutical Co., Ltd.
Brief Summary

Compare the Efficacy and Safety of Metformin/Rosuvastatin Combination Therapy With Metformin or Rosuvastatin Monotherapy in Patients With Type 2 Diabetes and Dyslipidemia

Detailed Description

Multi-center, Randomized, Double-blind, Phase III clinical trial

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
237
Inclusion Criteria
  • Over 19 years
  • Type II DM with Dyslipidemia
  • 6.5% ≤ HbA1c < 11%
  • Triglyceride < 350mg/dL
  • 100mg/dL ≤ LDL-C ≤ 250mg/dL
  • FPG ≤ 270mg/dL
Exclusion Criteria
  • Type I DM
  • Unstable angina, MI, Stroke, CABG with 6 month from screening
  • SBP ≥ 180mmHg, DBP ≥ 110mmHg
  • TSH > UNL
  • Heart failure (NYHA class III/IV)
  • Serum Creatinine > UNL or CLCr < 60 mL/min
  • CK ≥ 2x UNL
  • HIV positive
  • BMI > 40 kg/m^2

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Group IIIplacebo + RosuvastatinPlacebo + Rosuvastatin, Dosing to Type II DM with Dyslipidemia
Group IMetformin + RosuvastatinMetformin + Rosuvastatin, Dosing to Type II DM with Dyslipidemia
Group IIMetformin + placeboMetformin + placebo, Dosing to Type II DM with Dyslipidemia
Primary Outcome Measures
NameTimeMethod
change of HbA1c16 weeks from baseline
LDL-C (% change)16 weeks from baseline
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (33)

Youngnam University Hostpital

🇰🇷

Daegu, Korea, Republic of

Myoung Ji Hospital

🇰🇷

Gyeonggi-do, Korea, Republic of

Daeheon Eulji Medical Center

🇰🇷

Daejeon, Korea, Republic of

Gachon Gil Hospital

🇰🇷

Incheon, Korea, Republic of

Hallym University Sacred Heart hospital

🇰🇷

Gyeonggi-do, Korea, Republic of

Inje University Ilsan paik hospital

🇰🇷

Gyeonggi-do, Korea, Republic of

BunDang Jesang Hospital(DMC)

🇰🇷

Gyeonggi-do, Korea, Republic of

HanYang University Guri Hospital

🇰🇷

Gyeonggi-do, Korea, Republic of

Hallym University Kangnam Sacred Heart hospital

🇰🇷

Seoul, Korea, Republic of

Inchoen St. mary's Hospital

🇰🇷

Incheon, Korea, Republic of

KangBuk SamSung Hospital

🇰🇷

Seoul, Korea, Republic of

KyungHee University Hospital at Gangdong

🇰🇷

Seoul, Korea, Republic of

KonYang University Hostpital

🇰🇷

Daejeon, Korea, Republic of

KonKuk University Medical Center

🇰🇷

Seoul, Korea, Republic of

Ajou University hospital

🇰🇷

Suwon, Korea, Republic of

Korea University Anam Hospital

🇰🇷

Seoul, Korea, Republic of

Kangdong Sacred Heart Hospital

🇰🇷

Seoul, Korea, Republic of

Seoul National University Hospital

🇰🇷

Seoul, Korea, Republic of

SoonChunHayng University Hospital Seoul

🇰🇷

Seoul, Korea, Republic of

Wonju Severance Christian hospital

🇰🇷

Wŏnju, Korea, Republic of

Buchoen St. mary's Hospital

🇰🇷

Bucheon, Korea, Republic of

SeJong Hostpital

🇰🇷

Bucheon, Korea, Republic of

SoonChunHyang University Bucheon Hospital

🇰🇷

Bucheon, Korea, Republic of

Daegu Catholic University Medical Center

🇰🇷

Daegu, Korea, Republic of

InJe University Busan paik Hospital

🇰🇷

Busan, Korea, Republic of

Eulji Hospital Nowon

🇰🇷

Seoul, Korea, Republic of

Inje University Haeundae paik hospital

🇰🇷

Busan, Korea, Republic of

Chosun University Hospital

🇰🇷

Gwangju, Korea, Republic of

Seoul National University Hospital(Famlily medicine)

🇰🇷

Seoul, Korea, Republic of

Samsung Medical Center

🇰🇷

Seoul, Korea, Republic of

The catholic University of Korea YEOUIDO St mary's Hospital

🇰🇷

Seoul, Korea, Republic of

Severance hospital

🇰🇷

Seoul, Korea, Republic of

Korea University Guro hospital

🇰🇷

Soeul, Korea, Republic of

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