Cyanoacrylate Tissue Adhesives Versus Silk Suture at the Palatal Donor Site of Sub Epithelial Connective Tissue Graft

Not Applicable

• Conditions: The Effect of Local Aplication of Cayanoacrylate Tissue Adhesives on Improving the Healing
• Interventions: Procedure: Silk suture; Procedure: Cayanoacrylate tissue adhesives

• Registration Number: NCT04780360
• Lead Sponsor: Cairo University

Brief Summary

Subepithelial connective tissue grafts (CTG) are considered the gold standard procedure with proven clinical success when it comes to gingival augmentation aims to to improve periodontal health, which can enhance the long-term prognosis of teeth by obtaining soft tissue coverage of exposed root surfaces and/or augmentation the dimensions of gingival tissue. The procedure require harvesting tissue from a the palate, which increases the complexity of the procedure and patient discomfort. Complications after harvesting a graft would be pain, inflammation, bleeding, flap necrosis and infection in the donor site.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-11-17
• Study Start: 2021-02-01
• Study First Submitted QC: 2021-02-28
• Status Verified: 2021-03
• Study First Posted: 2021-03-03
• Last Update Submitted: 2021-03-04
• Last Update Posted: 2021-03-08
• Primary Completion: 2021-12-01
• Study Completion: 2021-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Patients with mucogingival defects scheduled for sub epithelial connective tissue graft
• Age at least 18 years.
• Not having any systemic disease that could compromise wound healing
• No periodontal surgery on the experimental sites.
• No smoking,
• No pregnancy or lactation

Exclusion Criteria

• Patients with coagulation disorders
• patients on corticosteroids, with uncontrolled diabetes, or with any systemic disease that precluded periodontal surgery
• patients with a history of contact dermatitis to formaldehyde
• Loss of maxillary premolars and molars
• Medications or antibiotics used in the previous 6 months
• Pregnancy or lactation
• Smoking

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Silk suture material	Silk suture	interrupted knots
Cayanoacrylate tissue adhesives	Cayanoacrylate tissue adhesives	thin layers of high viscosity blend of n-butyl and 2-octyl cayanoacrylate tissue adhesive will be applied and rinsed with saline at least three times with interval of at least 30 seconds

Primary Outcome Measures

Name	Time	Method
Early Wound Healing	1 week	Measured By Modified Early Wound Healing Index

Trial Locations

Locations (1)

Faculty of Dentistry, Cairo Universty; 🇪🇬 Cairo, Egypt