Thrombotic Biomarkers to Predict Thrombosis in Heparin-induced Thrombocytopenia
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 主要终点
- Deaths
研究概览
简要总结
Heparin induced thrombocytopenia (HIT) is a kind of catastrophic thrombotic complications after the application of heparin. If HIT without treatment, death rate is as high as 30% to 50%. Early diagnosis of HIT and prevention of thrombosis is very important.
This study is planned to assess the use of thrombotic biomarkers in patients with HIT, including thrombin-antithrombin complex, d-dimer, fibrin degradation products and Thrombelastograghy monitoring . These biomarkers are monitored in 5-14 days post-operation to assess the risk of thrombosis in HIT patients. All patients were followed up for 30 days, and clinical outcomes, including new thrombus and death, were recorded during follow-up.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospitalized patients undergoing cardiac surgery.
- •Receiving unfractionated heparin anticoagulation.
排除标准
- •history of heparin-induced thrombocytopenia
- •pregnant woman
结局指标
主要结局
Deaths
时间窗: 30 days
All-cause deaths
Thrombotic event
时间窗: 30 days
New thrombosis, including deep venous thrombosis,pulmonary embolism,Cerebral infarction,superior mesenteric artery embolism,artery embolism etc.
次要结局
未报告次要终点