Efficacy and Safety of Electrical Versus Pharmacological Cardioversion in Early Atrial Fibrillation: a Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 247
- 试验地点
- 1
- 主要终点
- Efficacy of intervention (Electrical and pharmacological cardioversion) in restoring sinus rythm
研究概览
简要总结
The optimal strategy to restore sinus rhythm in patients with atrial fibrillation (AF) of less than 48 hours' duration is still controversial. The investigators performed a controlled single-center trial to compare electrical and pharmacological (propafenone) cardioversion to restore the sinus rhythm in selected patients with acute atrial fibrillation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •atrial fibrillation of less than 48 hours' duration.
排除标准
- •AF of more than 48 hours'
- •hemodynamic instability
- •acute onset atrial fibrillation due to acute coronary syndrome
- •electrolyte disturbances
- •hypothermia
- •untreated hyperthyroidism
- •use of antiarrhythmic drugs
- •high embolic risk
- •unclear duration of symptoms
研究组 & 干预措施
electrical cardioversion
Patients were sedated with propofol and external cardioversion was performed in anteroposterior position (right sternal body at the third intercostal space-angle of the left scapula). Patients were submitted to a biphasic wave-form sequential shock of 100-150-200 J, if necessary.
干预措施: electrical cardioversion (Procedure)
propafenone
Propafenone (2 mg/kg bolus) was administered iv to obtain pharmacologic sinus rhythm conversion.
干预措施: propafenone (Drug)
结局指标
主要结局
Efficacy of intervention (Electrical and pharmacological cardioversion) in restoring sinus rythm
时间窗: during emergency department stay
次要结局
- Number of adverse events related to electrical and pharmacological cardioversion(during emergency department stay)
- recurrence of atrial fibrillation(within 2 months)