Efficacy and Safety of Electrical Versus Pharmacological Cardioversion in Early Atrial Fibrillation: a Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- electrical cardioversion
- Conditions
- Atrial Fibrillation
- Sponsor
- Valduce Hospital
- Enrollment
- 247
- Locations
- 1
- Primary Endpoint
- Efficacy of intervention (Electrical and pharmacological cardioversion) in restoring sinus rythm
- Status
- Completed
- Last Updated
- 16 years ago
Overview
Brief Summary
The optimal strategy to restore sinus rhythm in patients with atrial fibrillation (AF) of less than 48 hours' duration is still controversial. The investigators performed a controlled single-center trial to compare electrical and pharmacological (propafenone) cardioversion to restore the sinus rhythm in selected patients with acute atrial fibrillation.
Investigators
Eligibility Criteria
Inclusion Criteria
- •atrial fibrillation of less than 48 hours' duration.
Exclusion Criteria
- •AF of more than 48 hours'
- •hemodynamic instability
- •acute onset atrial fibrillation due to acute coronary syndrome
- •electrolyte disturbances
- •hypothermia
- •untreated hyperthyroidism
- •use of antiarrhythmic drugs
- •high embolic risk
- •unclear duration of symptoms
Arms & Interventions
electrical cardioversion
Patients were sedated with propofol and external cardioversion was performed in anteroposterior position (right sternal body at the third intercostal space-angle of the left scapula). Patients were submitted to a biphasic wave-form sequential shock of 100-150-200 J, if necessary.
Intervention: electrical cardioversion
propafenone
Propafenone (2 mg/kg bolus) was administered iv to obtain pharmacologic sinus rhythm conversion.
Intervention: propafenone
Outcomes
Primary Outcomes
Efficacy of intervention (Electrical and pharmacological cardioversion) in restoring sinus rythm
Time Frame: during emergency department stay
Secondary Outcomes
- Number of adverse events related to electrical and pharmacological cardioversion(during emergency department stay)
- recurrence of atrial fibrillation(within 2 months)