Study of the positron emission tomography (PET) tracer for tau 18F-PI-2620 in individuals with Down syndrome

Institut de Recerca HSCSP0 个研究点目标入组 80 人开始时间: 2020年6月4日最近更新: 2021年8月30日

试验速览

暂无简介。

•Criteria of control subjects:
•- Men and women with age> 35 years.
•- Absence of cognitive complaints.
•- Normal neuropsychological examination with MMSE scores between 24 and 30, absence of subjective memory complaints or objective memory deficit (measured with the Free and Cued Selective Reminding Test - FCSRT- (Grober, Buschke et al. 1988)) with a scalar score equal to or greater than 8 and a clinical dementia rating scale (CDR) score of 0 (Morris 1993).
•- Understand and accept the study procedures and sign an informed consent (guardian and / or patient).
•Inclusion criteria for participants with DS:
•- Men and women diagnosed with DS> 35 years.
•- Intellectual quotient> 34 (equivalent to mild and moderate mental retardation according to ICD-10 criteria).
•- Existence of reliable informant.
•- Participants / legal guardians who sign the IC for inclusion in the study.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 80
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•- Not meeting the inclusion criteria.
•- Severe depression (Geriatric scale score Scale depression> 20).
•- History of stroke, Hachinski score> 4 or previous neurological or psychiatric illness.
•- Confirmed pregnancy or possibility of pregnancy at the time of inclusion in the study.

发起方

Institut de Recerca HSCSP