Individualized homoeopathic treatment with consideration of accessory circumstances of chronic fatigue syndrome: An open label, single arm, clinical trial

Chronic fatigue syndrome [ICD-11 code 8E49], is characterized by severe, persistent exhaustion that significantly limits daily activities and is not relieved by rest. This fatigue often worsens with physical or mental exertion and is accompanied by other debilitating symptoms. In addition to fatigue, individuals may experience a range of symptoms, such as post-exertional malaise, neuro-cognitive symptoms (confusion or slow thinking), muscle pain, joint pain, sleep disturbances, hypersensitivity to stimuli, flu like symptoms, autonomic dysfunction (weakness and tremors), and immune system abnormalities that are usually made worse by exertion and not better explained by a different underlying aetiology. CFS is a severe illness that can lead to significant physical impairment, leaving patients immobile and requiring extensive care. This care may include hospitalizations for acute episodes, home support for daily activities, and outpatient management involving medications, physical therapy, and mental health services. Neuro-cognitive deficits, chronic exhaustion, and flu-like symptoms are some of the disease’s hallmarks.