Bleeding Risk in CVCs

Not Applicable

Completed

• Conditions: Bleeding

• Registration Number: NCT00448188
• Lead Sponsor: Heidelberg University

Brief Summary

Since many of the patients in an intensive care unit suffer from disorders of hemostasis, bleeding is a main concern applying central venous catheters. Even if there are some data indicating elevated international normalized ratio may not increase the risk of bleeding no clear cut-off has been defined so far. An INR \> 1.5 is generally considered to increase the risk of bleeding. Furthermore, many authors consider platelets below 50 x 109 /l as a contra-indication to CVC cannulation, since there are some data this may increase the risk of bleeding. Therefore platelet transfusion before venous puncture is suggested. In our clinical experience INR \> 1.5 and platelets \< 50 x 109 /l do not correlate with increased risk of bleeding. The aim of this study is to demonstrate, that coagulopathy, defined by INR and platelet count, is not decisive for bleeding.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-11
• Study Completion: 2007-03
• Study First Submitted: 2007-03-14
• Study First Submitted QC: 2007-03-15
• Study First Posted: 2007-03-16
• Status Verified: 2007-09
• Last Update Submitted: 2013-01-25
• Last Update Posted: 2013-01-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• All patients acquiring a central venous catheter

Exclusion Criteria

• Patients pre or post surgery
• Patients with bleeding due to other reason

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Bleeding within 24 hours after cvc application
other complications within the first 24 hours

Secondary Outcome Measures

Name	Time	Method
mortality
long-term complications

Trial Locations

Locations (1)

University Hospital Heidelberg; 🇩🇪 Heidelberg, Germany