Effect of low-dose esketamine on postoperative delirium in patients undergoing noncardiac surgery.

Phase 3

Completed

• Conditions: Postoperative confusion after noncardiac surgery; 10012221; 10043413

• Registration Number: NL-OMON38654
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2014-11-27
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 70

Inclusion Criteria

- The patient has provided written informed consent.
- Age >= 65 years.
- The patient is planned for hip or knee replacement surgery or major/peripheral vascular surgery under general anesthesia, with a scheduled duration of more than one hour and a minimal hospitalization of three days.

Exclusion Criteria

- The patient has severe systemic disease that limits activity and is a constant threat to life (ASA IV).
- The patient has a active of psychiatric disorders.
- The patient has an active infection and/or fever is present
- The patient has a history of hypersensitivity to one of the study drugs.
- The patient has a MMSE score below 24 points.
- The procedure will be performed under spinal anesthesia or any other locoregional technique.
- Prolonged sedation after surgery for more than 24 hours

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The incidence of a postoperative delirium.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The effect of esketamine on the bloodlevels on some biomarkers.</p><br>