The Influence of Thirty-degree Leg Elevation on Noradrenaline Requirements Administered as a Prophylactic Variable Infusion During Cesarean Delivery: An Open Label Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Average noradrenaline requirements
研究概览
简要总结
Spinal anesthesia is a widely chosen technique in obstetric theaters due to several advantages, however sympathetic block results in hypotension that carry several consequences on maternal and fetal health, thus early prediction and management takes high priority. in this regards recent recommendations suggest the use of prophylactic vasopressors like noradrenaline, researchers of this study aimed to explore the impact of leg elevation on prophylactic noradrenaline dose
详细描述
after spinal anesthesia, patients will be randomly allocated into 2 groups : Leg elevation group and control group.
noradrenaline will be used as variable infusion starting from 0.05 microgram/kg/min up to 0.14 microgram /kg/minute.
noradrenaline infusion will be continued till delivery of the baby
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •full term
- •singleton pregnancy
排除标准
- •decline to participate
- •baseline SBP <100 mmHg
- •failed spinal anesthesia
- •allergy to local anesthetic
- •coagulopathy
研究组 & 干预措施
Leg elevation group
leg will be elevated 30 degrees immediately after spinal anesthesia
干预措施: Leg elevation (Device)
Control group
Legs will remain supine after spinal anesthesia
结局指标
主要结局
Average noradrenaline requirements
时间窗: baseline to delivery of the baby
average noradrenaline requirements in both groups (mcg/kg/min)
次要结局
- Total noradrenaline requirements(baseline to delivery)
- incidence of spinal hypotension(baseline to delivery)
- incidence of severe hypotension(baseline to delivery)
研究者
Mina Adolf Helmy
lecture of anesthesia and critical care Cairo University
Cairo University