Microarchitecture of Vitreoretinal Contact
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- the ILM thickness in the macular zone (foveola)
研究概览
简要总结
Investigation of the vitreoretinal contact microarchitecture in the macular and paramacular zones of the human retina.
详细描述
Purpose: to study the features of the macular ILM, to study the features of the preretinal structures of the vitreous body of the Central retinal region, morphofunctional features of preretinal hyalocytes, and the mechanism of vitreoretinal adhesion.
Study Protocol: examination of donor human eyes obtained from an eye Bank after sampling material for corneal transplantation.
Research method: scanning electron microscopy (SEM) of the central retina (macular and paramacular zone): ILM, preretinal vitreous.
Scientific hypothesis: vitreoretinal adhesion is provided not by laminin and fibronectin, but by the interweaving of vitreous collagen fibers between the epiretinal vitreous (more firmly fixed to the retinal surface) and the cortical vitreous.
Expected results: determination of ILM thickness in the macular zone, microanatomy of preretinal vitreous strutcures, and possible mechanism of vitreoretinal adhesion, establishing the possibility of intravital synthesis of collagen fibers synthesis in the adult vitreous.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •eyes from donors without concomitant multiple organ pathology and ophthalmic pathology
排除标准
- •eye injury, age over 45 years, concomitant multiple organ pathology, previous eye diseases
结局指标
主要结局
the ILM thickness in the macular zone (foveola)
时间窗: within 3 days after receiving the cadaver eyes
the ILM thickness in the macular zone (foveola) in mkm by scanning electron microscopy data
superficial microstructure of ILM
时间窗: within 3 days after receiving the cadaver eyes
by scanning electron microscopy data
features of the structural microarchitecture of the preretinal vitreous in the macular zone
时间窗: within 3 days after receiving the cadaver eyes
by scanning electron microscopy data
morphofunctional features of preretinal hyalocytes.
时间窗: within 3 days after receiving the cadaver eyes
by scanning electron microscopy data
次要结局
未报告次要终点
研究者
Lyskin Pavel Vladimirovich, MD, PhD
MD, PhD, ophthalmosurgeon
The S.N. Fyodorov Eye Microsurgery State Institution