A Multicenter Clinical Study on the Detection of Pathogenic Microorganisms in Adult Severe Pneumonia Patients in Liaoning Province
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pathogenic Microorganism of Serious Pneumonia
- Sponsor
- Shengjing Hospital
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- Pathogenic microorganism spectrum of adult severe pneumonia in Liaoning Province
- Last Updated
- 4 years ago
Overview
Brief Summary
This study aimed to evaluate pathogenic microorganisms in adult severe pneumonia patients in different cities of Liaoning Province
Detailed Description
The pathogenic microorganisms of adult patients with severe pneumonia is detected in this study. Clinical treatment does not involve , so it meets the ethical requirements. The clinical data, laboratory test results and imaging data of adult severe pneumonia patients in different hospitals in different cities are recorded. The pathogenic microorganism is detected by second-generation sequencing of lower respiratory tract sputum or alveolar lavage fluid samples, and the data were sorted out to draw the pathogenic microorganism spectrum of adult severe pneumonia in Liaoning area. It will be used to guide clinical empirical treatment.
Investigators
Hongyu Zhao
deputy director of emergency department
Shengjing Hospital
Eligibility Criteria
Inclusion Criteria
- •Meet the standard of severe pneumonia： Main standards： Requiring mechanical ventilation or septic shock requiring vasoconstrictor therapy.
- •Secondary standards：(only if 3 items are met) Disturbance of consciousness; respiratory rate ≥ 30 times/min; PaO2/FiO2 ≤ 250, or PaO2 \< 60mmHg; azotemia (BUN ≥ 7.12mmol / L); hypotension requires strong fluid resuscitation; infiltration of multiple lobes; leucopenia (WBC \< 4 × 109 / L); thrombocytopenia (\< 10 × 109 / L); hypothermia (T \< 36 ℃).
Exclusion Criteria
- •refuse to sign informed consent; inaccurate results due to unqualified sputum or BALF samples
Outcomes
Primary Outcomes
Pathogenic microorganism spectrum of adult severe pneumonia in Liaoning Province
Time Frame: 2020.7-2023.12
Detection of pathogenic microorganisms in severe pneumonia by second generation sequencing