Pathogenic Microorganisms in Adult Severe Pneumonia Patients

• Conditions: Pathogenic Microorganism of Serious Pneumonia

• Registration Number: NCT04433403
• Lead Sponsor: Shengjing Hospital

Brief Summary

This study aimed to evaluate pathogenic microorganisms in adult severe pneumonia patients in different cities of Liaoning Province

Detailed Description

The pathogenic microorganisms of adult patients with severe pneumonia is detected in this study. Clinical treatment does not involve , so it meets the ethical requirements. The clinical data, laboratory test results and imaging data of adult severe pneumonia patients in different hospitals in different cities are recorded. The pathogenic microorganism is detected by second-generation sequencing of lower respiratory tract sputum or alveolar lavage fluid samples, and the data were sorted out to draw the pathogenic microorganism spectrum of adult severe pneumonia in Liaoning area. It will be used to guide clinical empirical treatment.

Study Timeline

• Study First Submitted: 2020-06-13
• Study First Submitted QC: 2020-06-13
• Study First Posted: 2020-06-16
• Study Start: 2020-07-01
• Status Verified: 2021-09
• Last Update Submitted: 2021-09-20
• Last Update Posted: 2021-09-22
• Primary Completion: 2023-12-31
• Study Completion: 2024-06-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Meet the standard of severe pneumonia： Main standards： Requiring mechanical ventilation or septic shock requiring vasoconstrictor therapy.

Secondary standards：(only if 3 items are met) Disturbance of consciousness; respiratory rate ≥ 30 times/min; PaO2/FiO2 ≤ 250, or PaO2 < 60mmHg; azotemia (BUN ≥ 7.12mmol / L); hypotension requires strong fluid resuscitation; infiltration of multiple lobes; leucopenia (WBC < 4 × 109 / L); thrombocytopenia (< 10 × 109 / L); hypothermia (T < 36 ℃).

Exclusion Criteria

• refuse to sign informed consent; inaccurate results due to unqualified sputum or BALF samples

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pathogenic microorganism spectrum of adult severe pneumonia in Liaoning Province	2020.7-2023.12	Detection of pathogenic microorganisms in severe pneumonia by second generation sequencing

Trial Locations

Locations (1)

Shengjing hospital of China Medical University; 🇨🇳 Shenyang, Liaoning, China