The Effect of Dietary Bioactive Compounds on Skin Health in Humans in Vivo
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 95
- 试验地点
- 1
- 主要终点
- Change in the minimum erythemal dose (MED) of ultraviolet radiation.
研究概览
简要总结
There is little information on the effect of oral bioactive compounds on human skin clinically despite evidence of a beneficial effect from laboratory studies. The aim of this study is to examine the effect of oral bioactive compounds (green tea and vitamin C) on the health of human skin by measuring markers of skin health directly and skin nutrient uptake.
详细描述
There is little information on the effect of oral catechin, a nutritionally relevant bioactive compound, on skin health in humans in vivo despite considerable evidence for protective effects in experimental studies. Vitamin C is essential for skin health and stabilises catechins in the gut lumen. Ultraviolet radiation (UVR) in sunlight is a key environmental stressor impacting on skin health. Effects include acute inflammation and longer term photodamage.
OBJECTIVE: To examine the protective effect of catechin and vitamin C on UVR-induced inflammation.
STUDY DESIGN
(1) A double-blind randomised controlled nutritional study in 50 healthy volunteers. Volunteers will receive 3 months dietary supplement with high dose bioactive (n=25),or placebo (n=25).
The aim is to quantify the influence of catechin/vitamin C on:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults
- •Sun-reactive skin type I / II
排除标准
- •History of skin cancer
- •History of a photosensitivity disorder
- •History of a generalised skin disorder
- •Sunbathing (including sunbeds) in the past 3 months
- •Pregnancy
- •Taking photoactive medicine
- •Drink tea > 2 cups/day
- •Taking nutritional supplements
结局指标
主要结局
Change in the minimum erythemal dose (MED) of ultraviolet radiation.
时间窗: 3 months
The UV minimum erythemal dose (MED) will be determined for each study volunteer before and after nutritional supplementation to examine if the intervention can increase the MED and therefore protect against UV-induced erythema.
次要结局
- Intergroup comparison of inflammatory mediators (cytokines/chemokines) in skin biopsy sections and blister fluid.(3 months)
- Intergroup comparison of histological biomarkers (leucocytes, markers of photoageing, DNA damage) in skin biopsy sections.(3 months)
- Nutrient (polyphenol) bioavailability in samples of skin, blood and urine.(3 months)
研究者
Lesley Rhodes
Professor of Experimental Dermatology
University of Manchester