Genetics of Fibromyalgia

• Conditions: Irritable Bowel Syndrome; Chronic Fatigue Syndrome; Fibromyalgia; Depression

• Registration Number: NCT00071162
• Lead Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Brief Summary

The Fibromyalgia Family Study identifies and collects blood samples from families with two or more members affected with Fibromyalgia Syndrome (FMS). The primary goal of the study is to identify genes that predispose people to FMS and/or symptoms related to FMS; identifying these genes may lead to a better understanding of the disease and more effective treatments.

Detailed Description

FMS predominantly affects women and is characterized by chronic widespread musculoskeletal pain, fatigue, sleep disturbance, and multiple tender points on physical examination. The pathophysiological mechanisms underlying FMS are not clearly understood, but neuroendocrine factors seem to be of major importance. Studies of familial association suggest that genetic factors play a role in FMS. This study will establish patterns of genetic linkage in families with FMS.

Participating family members will undergo a brief physical exam (including tender point exam), donate a blood sample, and complete a detailed questionnaire that includes experience with pain, fatigue, depression, bowel symptoms, headache, anxiety, and physical limitations. Measurements of serum serotonin and related compounds will also be obtained. To detect genetic factors, a genome-wide linkage scan using 405 microsatellite markers will be performed.

Study Timeline

• Study Start: 1999-09
• Study First Submitted: 2003-10-14
• Study First Submitted QC: 2003-10-14
• Study First Posted: 2003-10-15
• Status Verified: 2009-03
• Last Update Submitted: 2009-03-31
• Last Update Posted: 2009-04-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 560

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (4)

University of Texas Health Sciences Center; 🇺🇸 San Antonio, Texas, United States

University of Illinois at Peoria; 🇺🇸 Peoria, Illinois, United States

Case Western Reserve University; 🇺🇸 Cleveland, Ohio, United States

University of Cincinnati; 🇺🇸 Cincinnati, Ohio, United States