The Short Termed Efficacy of Ultrasound-Guided Hyaluronic Acid Injection into a Rheumatoid Ankle and Foot Joint: A Randomized Controlled Study
- Conditions
- The painful ankle and foot joints in patients with Rheumatoid arthritisHyaluronic acid,Ultrasound-guided,Ankle and foot,Rheumatoid arthritis,Synovitis,Color Doppler flow
- Registration Number
- TCTR20160417002
- Lead Sponsor
- Chen-Liang Chou
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 48
1)diagnosed with RA that met the ACR criteria28 for RA classification; 2)were aged>18years; 3)had a disease duration of at least 1year;4)had no ankle or foot joint deformity or ankylosis; and 5)had no active disease flare-up or other substantial ongoing active diseases,such as infections, and had a stable condition within 6 months. The disease activity was measured using disease activity scores-28 (DAS28).The level of disease activity can be interpreted as remission (DAS28≦2.6), low (2.65.1),according to the European League Against Rheumatism(EULAR) response criteria.
Patients were excluded if their treatment needed to be changed immediately; if they had changed their treatment protocol within 1 month; if they had substantial active diseases, such as infections, or a history of allergy to lidocaine (LI) or HA injection ;or if they had a history of traumatic ankle or foot injury with bone destruction.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Foot function index ,VAS baseline 2nd week 4th week By asking patients,color flow doppler baseline 2nd week 4th week Ultrasound
- Secondary Outcome Measures
Name Time Method Prevalence of pulmonary hypertension among patients with valvular heart disease undergoing surgery 1 year Review from echocardiographic report