Post-operative pain score comparison between additional intravenous dexmedetomidine, local dexmedetomidine, and placebo in patient undergoing elective open inguinal hernia repair under ilioinguinal/iliohypogastric (II/IH) nerve block and tumescent anesthesia.
- Conditions
- postoperative pain after open inguinal hernia repairdexmedetomidine, inguinal hernia repair, ilioinguinal/iliohypogastric nerve block, tumescent anesthesia, pain
- Registration Number
- TCTR20220208002
- Lead Sponsor
- avamindradhiraj University Research Fund
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- nknown
- Sex
- All
- Target Recruitment
- 105
An adult patients age 18 - 75 years
uncomplicated inguinal hernia
fully inform consent
ASA classification I-III
Non pregnant woman
Non immunocompromised disease hosts including HIV, taking immunosuppressive drug, has ascites, morbid obesity
Emergency operation
Subject cannot communicate with outcome assessor such as deafness, mental problem.
Subject who is in bed ridden status.
Subject who have preexisting chronic pain or daily consumption greater than 20 mg of oral morphine equivalent
Subject who have either baseline heart rate less than 50 bpm, or atrioventricular block on 12-lead ECG
Subject who have history of study drug allergy including dexmedetomidine, bupivacaine, propofol, fentanyl, tramadol, celecoxib, paracetamol and sulfa.
Subject who have glomerular filtration rate less than or equal 30 mL per minute
Subject who have history of gastrointestinal bleeding, coronary artery bypass graft surgery, and myocardial infarction
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method VAS at 6 hours postoperatively at 6 hours VAS
- Secondary Outcome Measures
Name Time Method