Diagnostic Value of MRI for Allergic Broncho-Pulmonary Aspergilloses

Not Applicable

Completed

• Conditions: Allergic Bronchopulmonary Aspergilloses
• Interventions: Device: MRI; Device: CT scan (standard reference)

• Registration Number: NCT03265366
• Lead Sponsor: University Hospital, Bordeaux

Brief Summary

The aim of the study is to compare the concordance between chest computerized tomography-scan (CTscan) and Magnetic resonance Imaging (MRI) for the description of the abnormalities seen in Allergic BronchoPulmonary Aspergillosis (ABPA).

Detailed Description

The ABPA is responsible for pulmonary exacerbations in chronic bronchial diseases. The treatment of ABPA consists in systemic corticosteroids and anti fungal therapy, which can have severe side effects. The diagnosis is difficult, based on several but non-specific characteristics. One of the radiologic abnormalities on CTscan could be more specific : high attenuation in impacted mucus, but this sign is found in about 30% of cases. Recent articles and investigators experience seem to demonstrate that MRI could provide an interesting tool for ABPA diagnosis, studying the signal of bronchial impactions. The aim of the study is to describe the MRI characteristics of patients with ABPA and compare the results with those obtained by CTscan, and in order to determine if there is a specific signal of impaction in ABPA.

Study Timeline

• Study First Submitted: 2017-08-25
• Study First Submitted QC: 2017-08-25
• Study First Posted: 2017-08-29
• Study Start: 2017-09-14
• Primary Completion: 2020-01-24
• Study Completion: 2020-01-24
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-09
• Last Update Posted: 2022-02-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• study patients have a diagnosis of ABPA
• control patients have severe asthma
• All the patients are ≥ 18 years old, have social security care, signature of consent form

Exclusion Criteria

• cystic fibrosis
• other type of aspergilloses
• contraindication for MRI
• woman without effective contraception

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Severe asthma	CT scan (standard reference)	12 patients with severe asthma
ABPA	CT scan (standard reference)	15 patients with ABPA
ABPA	MRI	15 patients with ABPA
Severe asthma	MRI	12 patients with severe asthma

Primary Outcome Measures

Name	Time	Method
Concordance between chest CT scan and MRI for bronchial and pulmonary signs of ABPA (bronchiectases, infiltrates, impactions)	Day 0	Measured by a kappa test

Trial Locations

Locations (1)

CHU de Bordeaux; 🇫🇷 Pessac, France