Diagnostic Value of MRI for Allergic Broncho-Pulmonary Aspergilloses
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Concordance between chest CT scan and MRI for bronchial and pulmonary signs of ABPA (bronchiectases, infiltrates, impactions)
研究概览
简要总结
The aim of the study is to compare the concordance between chest computerized tomography-scan (CTscan) and Magnetic resonance Imaging (MRI) for the description of the abnormalities seen in Allergic BronchoPulmonary Aspergillosis (ABPA).
详细描述
The ABPA is responsible for pulmonary exacerbations in chronic bronchial diseases. The treatment of ABPA consists in systemic corticosteroids and anti fungal therapy, which can have severe side effects. The diagnosis is difficult, based on several but non-specific characteristics. One of the radiologic abnormalities on CTscan could be more specific : high attenuation in impacted mucus, but this sign is found in about 30% of cases. Recent articles and investigators experience seem to demonstrate that MRI could provide an interesting tool for ABPA diagnosis, studying the signal of bronchial impactions. The aim of the study is to describe the MRI characteristics of patients with ABPA and compare the results with those obtained by CTscan, and in order to determine if there is a specific signal of impaction in ABPA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •study patients have a diagnosis of ABPA
- •control patients have severe asthma
- •All the patients are ≥ 18 years old, have social security care, signature of consent form
排除标准
- •cystic fibrosis
- •other type of aspergilloses
- •contraindication for MRI
- •woman without effective contraception
研究组 & 干预措施
ABPA
15 patients with ABPA
干预措施: MRI (Device)
ABPA
15 patients with ABPA
干预措施: CT scan (standard reference) (Device)
Severe asthma
12 patients with severe asthma
干预措施: MRI (Device)
Severe asthma
12 patients with severe asthma
干预措施: CT scan (standard reference) (Device)
结局指标
主要结局
Concordance between chest CT scan and MRI for bronchial and pulmonary signs of ABPA (bronchiectases, infiltrates, impactions)
时间窗: Day 0
Measured by a kappa test
次要结局
未报告次要终点