Functional Outcomes of Arthroscopic Anterior Cruciate Ligament Reconstruction by Hamstring Graft With and Without Platelet-Rich Plasma
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Muhammad Aamir Latif
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Anterior Drawer's test
Overview
Brief Summary
No local data exists regarding the outcomes of anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma. This study aimed to compare the functional outcomes of arthroscopic anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma.
Detailed Description
In animal studies, platelet-rich plasma has shown excellent results in accelerating the healing of the anterior cruciate ligament, but studies on human have shown varying clinical outcomes when investigating platelet-rich plasma for its effects on anterior cruciate ligament reconstruction. The findings of this study could provide important insights about the possible role of platelet-rich plasma in arthroscopic anterior cruciate ligament reconstruction by hamstring graft. to enhance early graft healing and reduce early complications, though its long-term effectiveness remains inconsistent. Studies suggest PRP may improve short-to-medium term outcomes like reduced pain and enhanced knee function,
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 40 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Any gender
- •Aged 18-40 years
- •With clinically and radiologically confirmed arthroscopic evidence of ACL injury
Exclusion Criteria
- •With comprised bilateral ACL tears
- •Lack of fitness due to associated comorbidity
- •Fractures of lower limb bones and/or spine/neurovascular injuries
- •Injuries to other knee ligaments
- •Significant knee joint arthritis
- •Local skin infections
Outcomes
Primary Outcomes
Anterior Drawer's test
Time Frame: 12 weeks
Number of patients having grade-1 on the Anterior Drawer's test
Lachman's test
Time Frame: 12 weeks
Number of patients having grade-1 on the Lysholm knee score
Lysholm knee score
Time Frame: 12 weeks
A higher Lysholm knee score was labeled as effectiveness of the treatment.
Secondary Outcomes
No secondary outcomes reported
Investigators
Muhammad Aamir Latif
Research Consultant
RESnTEC, Institute of Research