Comparison of High Intensity Interval Body Weight Training Versus Combined Training on Body Composition, Physical Function, Metabolic Risk and Inflammation in Postmenopausal Women With and Without Gynecological Cancer
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Breast Cancer Female
- Sponsor
- Universidade Federal do Triangulo Mineiro
- Enrollment
- 38
- Primary Endpoint
- Body composition
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The study aim was to compare the effectiveness of combined training (CT; aerobic + resistance exercises) and high-intensity interval body weight training (HIITBW) on body composition, metabolic and inflammatory profile, physical function and quality of life in older women with gynecological and breast cancer and their pair-matched controls (older women with no cancer). The hypothesis of the present clinical trial is that HIITBW is effective as well as CT for improvements on body composition, metabolic and inflammatory profile, physical function and quality of life in older women with gynecological and breast cancer.
Detailed Description
Physical training has been recommended to prevent or attenuation cachexia and sarcopenia in older people with or without cancer. The American College of Sports Medicine recommends 150 min of moderate intensity exercise combining aerobic exercise with resistance exercises, termed as combined training (CT). However, it has been reported that very low proportion (\<10%) of older adults meet the physical activity recommendation. Lack of time has been reported as a common reason to people not to do exercise. Thus, identifying effective physical training dosages and modalities which may be feasible are necessary for this population. Repeated brief bouts of fast and intense exercise interspersed with low intensity exercise termed as high intensity interval training (HIIT) has shown to be a time-effective strategy to improve cardiorespiratory fitness in young and older. Moreover, HIIT has shown to improve glycemic control in patients at high risk for TDM2, muscle mass, body fat and physical function. However, there were many pending issues involving the HIIT for sarcopenia and cachexia in older people. For instance, the lack of access to physical activity facilities, such as the need for specific equipment (i.e. fitness equipment: treadmill, bike or resistance exercise equipment) and the need for high motor skill levels to performance the high-intensity exercise (i.e. run at high speed) have been reported as another reason to older people not to do HIIT. Different HIIT programs performed outside of laboratory has been proposed, especially with body-weight exercises. The high-intensity interval body weight training (HIBWT) is performed without equipment and with low motor skill levels. HIBWT has been shown to improve fat mass, muscle mass, cardiorespiratory capacity and physical performance in young adults with or without overweight. Despite this, no previous studies have evaluated HIBWT efficacy and safe in older people with sarcopenia and cachexia. The study aim was to compare the effectiveness of CT and HIITBW on body composition, metabolic and inflammatory profile, physical function and quality of life in older women with gynecological and breast cancer and their pair-matched controls (older women with no cancer). The hypothesis of the present clinical trial is that HIITBW is effective as well as CT for improvements on body composition, metabolic and inflammatory profile, physical function and quality of life in older women with gynecological and breast cancer.
Investigators
Fábio Lera Orsatti
Professor, PhD
Universidade Federal do Triangulo Mineiro
Eligibility Criteria
Inclusion Criteria
- •Postemenopausal women without cancer
- •Postemenopausal women with breast cancer
- •Postemenopausal women with gynecological cancer
Exclusion Criteria
- •No several physical limitations (wheelchair, canes or any similar device)
Outcomes
Primary Outcomes
Body composition
Time Frame: pre intervention and post intervention (i.e. 12 weeks)
Soft-tissue (fat mass, kg and lean mass, kg) of whole body and regional composition were assessed via dual-energy x-ray absorptiometry scanning (iDXA; GE Healthcare-Luna, Madison, WI; software Encore version 14.10)
Muscle strength
Time Frame: pre intervention and post intervention (i.e. 12 weeks)
It was measured by the one repetition maximum (1RM) test in the leg extension equipment.
Rate of force development (a critical component of muscle power)
Time Frame: pre intervention and post intervention (i.e. 12 weeks)
It was measured by a rapid maximum isometric voluntary contraction of the one-sidedly knee extension force pulses (Metrolog SD20-LVDT, São Carlos/SP, Brazil) of both legs.
Cardiorespiratory fitness
Time Frame: pre intervention and post intervention (i.e. 12 weeks)
The six-minute walk test and the one mile walk test was performed indoor, on a flat floor in a sports court.
Short physical performance battery (SPPB)
Time Frame: pre intervention and post intervention (i.e. 12 weeks)
The SPPB consisted of three tests performed in the following order: balance test, four-meter walk test, and five-time-sit-to-stand test. Each test score varied to zero to four points, and the SPPB total score varied to zero to 12 points (sum of the scores of the three tests).
Secondary Outcomes
- Citokines(pre intervention and post intervention (i.e. 12 weeks))
- Quality of life(pre intervention and post intervention (i.e. 12 weeks))
- Hormones(pre intervention and post intervention (i.e. 12 weeks))
- Metabolic markers(pre intervention and post intervention (i.e. 12 weeks))
- Electromyography(pre intervention and post intervention (i.e. 12 weeks))
- Physical activity level(pre intervention and post intervention (i.e. 12 weeks))
- Nutrition habits(pre intervention and post intervention (i.e. 12 weeks))
- Functional capacity(pre intervention and post intervention (i.e. 12 weeks))