Network Targeted Transcranial Direct Current Stimulation (tDCS) as a Treatment for Laryngeal Dystonia (LD)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Change in Cepstral peak prominence (CPP)
研究概览
简要总结
This project will apply transcranial direct current stimulation (tDCS) to multiple brain areas to evaluate the effects as a potential treatment for laryngeal dystonia (formerly spasmodic dysphonia).
详细描述
Baseline neuroimaging data will be acquired from all participants via MRI, EEG. Each participant will be seen for multiple testing sessions over a five day period. LD participants will undergo the neuromodulation (HD-tDCS Stimulation) for twenty minutes while engaged in watching videos/movies or performing a word production task.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
盲法说明
Subjects and staff will be blind during the study and that subjects will be told of their assignment at the follow-up visit.
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participants must be clinically evaluated for the diagnosis of LD or have the proof of LD diagnosis. (Not applicable for control participants)
- •No other known or history of speech, voice disorder other than LD.
- •Provision of signed and dated informed consent form.
- •Stated willingness to comply with all study procedures and availability for the duration of the study
- •Must not be pregnant.
排除标准
- •All individuals who do not meet the above mentioned criteria are excluded from the study.
- •Subjects with a history of epilepsy or depression or is claustrophobic.
研究组 & 干预措施
Laryngeal Dystonia (LD) tDCS
Adductor, Abductor and Mixed type LD with clinical evaluation of LD or with proof of LD diagnosis
干预措施: Starstim system (Device)
结局指标
主要结局
Change in Cepstral peak prominence (CPP)
时间窗: daily on Day 1-Day 5
Cepstral peak prominence (CPP) as a robust objective measure of voice quality in the active, sham and no stimulation conditions.
Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V)
时间窗: daily on Day 1-Day 5
Its primary purpose is to describe the severity of auditory-perceptual attributes of a voice problem, in a way that can be communicated among clinicians
次要结局
未报告次要终点