A Retrospective, Real-world Multicenter Study of DOstarlimab in Patients With Recurrent or Advanced DNA Mismatch Repair Deficient/Microsatellite Instability-high (dMMR/MSI-H) Endometrial Cancer (DORA Study)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Disease progression after dostarlimab
研究概览
简要总结
This is a multicenter, retrospective, observational (non-interventional) study, in patients treated in a real-world setting within the Spanish dostarlimab EAP. The study is planned to be conducted in the Medical Oncology departments at 50-60 Spanish GEICO-associated hospitals. Its multicenter nature aims to improve the representativeness of the study population in Spain. The study would include approximately 110 patients with dMMR/MSI-H recurrent or advanced EC, that have progressed on or following prior treatment with a platinum containing regimen, treated within the dostarlimab EAP, available in Spain from January 2021 to September 2022. The total number of participating centers and patients will be confirmed once the EAP is closed.
Patient's medical records will be screened by local clinical staff to assess for eligibility according to selection criteria. The study comprises a single study visit, in which the patient will give her informed consent to participate (when the patient is alive) and the physician will extract the study data from the patient's medical charts.
Alive patients who fulfill inclusion criteria and meet no exclusion criteria will be informed by a member of their care team about the purpose of the study, as well as about potential risks and benefits of study participation. The written informed consent form (ICF) should be signed prior to study initiation in alive patients in order to access their medical records. Deceased patients will be still included but their relatives will not be contacted. In these instances, data will be collected by members of the direct care team, unless there is a prior express order from the patient to preserve confidentiality. All eligible deceased and consenting living patients at the participating centers will be included. Data will be directly retrieved from hospital medical records and reported in the electronic Case Report Form (eCRF).
详细描述
1.1.1. Primary Clinical Objective
• To assess the antitumor activity of dostarlimab in patients with recurrent or advanced mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) endometrial cancer, in terms of objective response rate (ORR) and duration of response (DOR) based on investigators' assessment using Response Evaluation Criteria in Solid Tumors (RECIST) v1.1.
1.1.2. Secondary Clinical Objectives
- To assess the effectiveness of dostarlimab in terms of investigator-assessed progression-free survival (PFS) and overall survival (OS).
- To analyze the PFS rate at 6, 12, 18 and 24 months.
- To assess the disease control rate (DCR) based on investigators' assessment using RECIST 1.1.
- To evaluate duration of treatment with dostarlimab.
- To describe the time to response to dostarlimab.
- To evaluate the safety and tolerability of dostarlimab in patients with dMMR/MSI-H endometrial advanced cancer, including immune-related adverse events of interest (irAEI).
- To evaluate Neutrophil-to-lymphocyte ratio as a potential predictive biomarker for treatment with dostarlimab.
1.1.3. Translational Objectives
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •At least 18 years of age, able to understand the program procedures and agree to participate by providing written informed consent.
- •Histologically diagnosed endometrial cancer (note: all histologies are permitted except endometrial sarcoma [including carcinosarcoma]).
- •Patient has evidence of tumor DNA damage repair dysfunction (dMMR/MSI-H) via locally available, validated methodology.
- •Patient has progressed on or after platinum containing chemotherapy (and has received no more than 2 lines of anti-cancer therapy for recurrent or advanced (Stage ≥ IIIB) disease (first or second line)); prior treatment with hormone therapies is acceptable and does not count towards the number of lines of therapy.
- •ECOG performance status of ≤
- •Adequate organ and bone marrow function, as defined below:
- •Absolute neutrophil count (ANC) ≥ 1,500/µL
- •Platelets ≥ 100,000/µL
- •Hemoglobin ≥ 9 g/dL
- •Adequate liver and renal function:
- •Serum creatinine ≤ 1.5 × upper limit of normal (ULN) or calculated creatinine clearance ≥ 50 mL/min using Cockcroft-Gault equation for patients with creatinine levels > 1.5 × institutional ULN.
- •Total bilirubin ≤ 1.5 × ULN AND direct bilirubin ≤ 1 × ULN.
- •Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 × ULN unless liver metastases are present, in which case they must be ≤ 5 × ULN.
- •Cannot be satisfactorily treated with available alternative treatments.
- •Not eligible for a clinical trial with dostarlimab within the indication of the EAP (where access to the clinical trialsite is possible)
- •A female participant is eligible to participate if she is not pregnant or breastfeeding, and if one of the following conditions applies:
- •Is a woman of non-childbearing potential (WONCBP) OR
- •Is a WOCBP and using a contraceptive method that is highly effective (with a failurerate of < 1 % per year), preferably with low user dependency, during treatment and for at least 4 months after treatment. The treating physician should evaluate the potential for contraceptive method failure (e.g., noncompliance, recently initiated)in relationship to the first doseof dostarlimab.
- •A WOCBP must have a negative highly sensitive serum pregnancy test within 72 hours before the first dose of dostarlimab. The treating physician is responsible for review of medical history, menstrual history, andrecent sexual activity to decrease the risk for inclusion of a woman with an early undetected pregnancy
排除标准
- •Has received prior therapy with an anti-programmed death-1 (anti-PD-1), anti-PD-1- ligand-1 (anti-PD-L1), or anti-PD-1 ligand-2 (anti-PD-L2) agent.
- •Is considered a poor medical risk due to a serious, uncontrolled medical disorder, non malignant systemic disease, or active infection requiring antibiotic, antifungal or antiviral treatment.
- •Has undergone major surgery 3 weeks prior to initiating dostarlimab (and not recovered from surgical effects).
- •Has malignancies other than endometrial cancer (except for any other malignancy for which the patient is not being actively treated).
- •Has a history of interstitial lung disease.
- •Has an active autoimmune disease that required systemic treatment in the past 2 years (i.e., use of disease-modifying agents, corticosteroids, or immunosuppressive drugs); hormone replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment
- •Has experienced ≥ Grade 3 immune related AE with prior immunotherapy, except for non-clinically significant laboratory abnormalities.
- •Has known active hepatitis B (e.g., hepatitis B surface antigen [HBsAg] reactive) or hepatitis C (e.g., hepatitis C virus [HCV] ribonucleic acid [qualitative] is detected).
- •Has received a live vaccine within 14 days of 1st dose of dostarlimab.
- •Has a known hypersensitivity to dostarlimab components or excipients
研究组 & 干预措施
Case-only
The study population consists of adult female patients with diagnosis of dMMR/MSI-H recurrent or advanced endometrial cancer with progression to a previous platinum regimen, who were treated within the Spanish dostarlimab Expanded Access Program (EAP).
干预措施: Dostarlimab (Drug)
结局指标
主要结局
Disease progression after dostarlimab
时间窗: Month 4-6
Best Response Assessment
时间窗: Month 4-6
Dostarlimab -Related Adverse Events
时间窗: Month 4-6
Dostarlimab Treatment
时间窗: Month 4-6
Start date (first dose) End of treatment date
次要结局
- Subsequent Therapies for Endometrial Cancer(Month 4-6)
- Medical History(Month 4-6)
- Survival Status(Month 4-6)
- Endometrial Cancer History(Month 4-6)
- Endometrial Cancer Previous Treatments(Month 4-6)
- Demographics(Month 4-6)
- Baseline (pre-dostarlimab)(Month 4-6)
- Death(Month 4-6)