The impact of oral curcumin (Curcuma longa) on mycophenolic acid and metabolite pharmacokinetics in stable renal allograft recipients: exploratory investigation of the role of intestinal uridine-diphosphate-glucuronosyltransferases (UGTs) in in vivo mycophenolic acid disposition.
- Conditions
- Stable renal allograft recipients
- Registration Number
- EUCTR2007-003114-34-BE
- Lead Sponsor
- Department of Nephrology and Renal Transplantation, University Hospitals Leuven
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- All
- Target Recruitment
- 12
Primary and secondary renal allograft recipients.
Stable (clinically and biochemically) renal transplant patients.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Age < 18 yrs of age.
Combined solid organ transplantations.
History of medical or surgical diseases of the gastrointestinal and hepato-biliary tract.
Recipients with active infectious or inflammatory disease as well as anti-infectious or anti-inflammatory treatment for at least 2 weeks prior to enrolment.
Severe hypoalbuminemia (< 25 g/L).
Severe anemia (< 8 g/dL).
Patients with documented non-compliance.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method