TCTR20160902001Completed未知
The physiologic study of high-flow nasal oxygen cannula in patients with chronic obstructive pulmonary disease with acute exacerbation requiring ventilator support
Faculty of Medicine Siriraj Hospital0 sites12 target enrollmentStarted: September 2, 2016Last updated:
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Enrollment
- 12
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 40 Years to 85 Years (—)
- Sex
- All
Inclusion Criteria
- •1. Age 40-85 years old
- •2. Patients who was diagnosed COPD classified by GOLD criteria (post-bronchodilator FEV1/FVC < 70%)
- •3. Acute exacerbation of COPD with indication for NIV use as follows
- •- Acute respiratory acidosis (pH/=45 mmHg)
- •- Respiratory rate > 24 breaths/min
- •- Accessory muscles use or abdominal paradox breathing
Exclusion Criteria
- •1. pH < 7.25
- •2. Severe hypoxemia
- •3. Alteration of consciousness and uncooperative (GCS < 8)
- •4. Hemodynamic instability or serious cardiac problem e.g hypotension, malignant arrhythmia, myocardial ischemia
- •5. Facial abnormality or recent facial/upper GI tract surgery
- •6. Uncontrolled airway or upper GI bleeding
- •7. Contraindication for insertion of esophageal balloon catheter - ulcer, varices, tumor, recent esophageal/gastric surgery, bleeding diathesis or allergy to lidocaine
Investigators
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