The physiologic study of high-flow nasal oxygen cannula in patients with chronic obstructive pulmonary disease with acute exacerbation requiring ventilator support
- Conditions
- Patients with chronic ostructive pulmonary disease presented with acute exacerbation and requiring non-invasive ventilationChronic obstructive pulmonary diseaseHigh-flow nasal oxygen cannulaNon-Work of breathing
- Registration Number
- TCTR20160902001
- Lead Sponsor
- Faculty of Medicine Siriraj Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 12
1. Age 40-85 years old
2. Patients who was diagnosed COPD classified by GOLD criteria (post-bronchodilator FEV1/FVC < 70%)
3. Acute exacerbation of COPD with indication for NIV use as follows
- Acute respiratory acidosis (pH/=45 mmHg)
- Respiratory rate > 24 breaths/min
- Accessory muscles use or abdominal paradox breathing
1. pH < 7.25
2. Severe hypoxemia
3. Alteration of consciousness and uncooperative (GCS < 8)
4. Hemodynamic instability or serious cardiac problem e.g hypotension, malignant arrhythmia, myocardial ischemia
5. Facial abnormality or recent facial/upper GI tract surgery
6. Uncontrolled airway or upper GI bleeding
7. Contraindication for insertion of esophageal balloon catheter - ulcer, varices, tumor, recent esophageal/gastric surgery, bleeding diathesis or allergy to lidocaine
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
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