The physiologic study of high-flow nasal oxygen cannula in patients with chronic obstructive pulmonary disease with acute exacerbation requiring ventilator support

Faculty of Medicine Siriraj Hospital0 sites12 target enrollmentSeptember 2, 2016

Overview

Phase: 未知
Intervention: Not specified
Conditions: Patients with chronic ostructive pulmonary disease presented with acute exacerbation and requiring non&#45
Sponsor: Faculty of Medicine Siriraj Hospital
Enrollment: 12
Status: Completed
Last Updated: last year

No summary available.

Registry

who.int

Start Date

September 2, 2016

End Date

February 28, 2017

Last Updated

last year

Study Type

Interventional

Sex

All

Sponsor

•1\. Age 40\-85 years old
•2\. Patients who was diagnosed COPD classified by GOLD criteria (post\-bronchodilator FEV1/FVC \< 70%)
•3\. Acute exacerbation of COPD with indication for NIV use as follows
•\- Acute respiratory acidosis (pH/\=45 mmHg)
•\- Respiratory rate \> 24 breaths/min
•\- Accessory muscles use or abdominal paradox breathing

•1\. pH \< 7\.25
•2\. Severe hypoxemia
•3\. Alteration of consciousness and uncooperative (GCS \< 8\)
•4\. Hemodynamic instability or serious cardiac problem e.g hypotension, malignant arrhythmia, myocardial ischemia
•5\. Facial abnormality or recent facial/upper GI tract surgery
•6\. Uncontrolled airway or upper GI bleeding
•7\. Contraindication for insertion of esophageal balloon catheter \- ulcer, varices, tumor, recent esophageal/gastric surgery, bleeding diathesis or allergy to lidocaine