The physiologic study of high-flow nasal oxygen cannula in patients with chronic obstructive pulmonary disease with acute exacerbation requiring ventilator support

Not Applicable

Completed

• Conditions: Patients with chronic ostructive pulmonary disease presented with acute exacerbation and requiring non- invasive ventilation; Chronic obstructive pulmonary disease; High- flow nasal oxygen cannula; Non- Work of breathing

• Registration Number: TCTR20160902001
• Lead Sponsor: Faculty of Medicine Siriraj Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-09-02
• Study Completion: 2017-02-28
• Last Update Posted: 2024-08-19

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

1. Age 40-85 years old
2. Patients who was diagnosed COPD classified by GOLD criteria (post-bronchodilator FEV1/FVC < 70%)
3. Acute exacerbation of COPD with indication for NIV use as follows
- Acute respiratory acidosis (pH/=45 mmHg)
- Respiratory rate > 24 breaths/min
- Accessory muscles use or abdominal paradox breathing

Exclusion Criteria

1. pH < 7.25
2. Severe hypoxemia
3. Alteration of consciousness and uncooperative (GCS < 8)
4. Hemodynamic instability or serious cardiac problem e.g hypotension, malignant arrhythmia, myocardial ischemia
5. Facial abnormality or recent facial/upper GI tract surgery
6. Uncontrolled airway or upper GI bleeding
7. Contraindication for insertion of esophageal balloon catheter - ulcer, varices, tumor, recent esophageal/gastric surgery, bleeding diathesis or allergy to lidocaine

Study & Design

• Study Type: Interventional
• Study Design: Not specified