Improving Cognitive Aptitudes With tDCS in Patients With Multiple Sclerosis / Améliorer Les capacités Cognitives Par tDCS Chez Les Patients Souffrants de sclérose en Plaques
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Relapsing Remitting Multiple Sclerosis
- Sponsor
- University Hospital of Mont-Godinne
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Enhancement of Cognitive aptitudes with tDCS
- Status
- Terminated
- Last Updated
- 2 years ago
Overview
Brief Summary
Noninvasive brain stimulations (NIBS) will be used in MS patients with cognitive impairments to enhance their cognitive aptitudes.
Detailed Description
tDCS will be used in a sham-controlled, double-blind, randomized, cross-over control trial in MS patients suffering from cognitive impairments and/or motor deficits. After informed consent and recruitment, patients will be randomly (computer method) allocated to real or sham tDCS, that will be applied during working memory and attentional tasks. A few days/weeks after completing one arm, the patients will enter the other arm (double-blind cross-over design). Baseline and follow-up outcomes about cognitive aptitudes, motor tasks and fatigue will be collected.
Investigators
Pr Yves Vandermeeren, MD, PhD
Professor
University Hospital of Mont-Godinne
Eligibility Criteria
Inclusion Criteria
- •MS patients with relapsing remitting MS/secondary progression MS (based on the 2010 revised McDonald criteria)
- •Cognitive deficits
- •Motor deficits
Exclusion Criteria
- •contraindication to tDCS (seizure or epilepsy, metal in the head, ...)
- •major psychiatric conditions or major depression
- •coexisting instable medical condition
- •substance or alcohol abuse
- •regular intake of drug that strongly modulate brain excitability
- •major sequels from MS preventing participation in the study
- •pregnancy
Outcomes
Primary Outcomes
Enhancement of Cognitive aptitudes with tDCS
Time Frame: from baseline to 4 weeks after the intervention
The effect of intervention on attentional, working memory and executive function deficits will be quantified by means of validated tests before and after intervention.
Secondary Outcomes
- Enhancement of Motor skills with tDCS(from baseline to 4 weeks after the intervention)
- Impact on Fatigue and Enhancement of Cognitive performances with tDCS(from baseline to 4 weeks after the intervention)